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QuickView for FKBP1A;jsessionid=A69CC6E971259041B9FB193501C704E0;jsessionid=E77FE0CB719928D460BF5C30214701E1 (gene)


Gene Symbol:
Fkbp1a Rattus norvegicus Rattus norvegicus
Full name:
FK506 binding protein 1a
Synonyms:
FKBP12, Fkbp2, peptidyl-prolyl cis-trans isomerase FKBP1A, 12 kDa FK506-binding protein, 12 kDa FKBP, FK506 binding protein 2 (13 kDa), FK506-binding protein 1 (12kD), FK506-binding protein 1A, FKBP-12, FKBP-1A, PPIase FKBP1A, immunophilin FKBP12, rotamase
Genomic Location:
Chr 3: 141861237-141880797
Description:
mediates islet microsome Ca2+ release through binding to ryanodine receptor (RyR) and catalyzes the cis-trans isomerization of peptidyl-prolyl amide peptide bonds
Orthologs:
Homo sapiens Mus musculus Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_013102
XM_001053006
XM_001053007
Protein Names
Q62658
A0JN04
P97533



GO Molecular Function

FK506 binding | channel regulator activity | isomerase activity | enzyme binding | protein-containing complex binding | transforming growth factor beta receptor binding | ion channel inhibitor activity | signaling receptor binding | cytokine receptor binding | molecular function regulator | catalytic activity | ion channel binding | Hsp70 protein binding | channel inhibitor activity | activin binding | identical protein binding | peptidyl-prolyl cis-trans isomerase activity | organic cyclic compound binding | type I transforming growth factor beta receptor binding | protein binding | protein homodimerization activity | calcium channel regulator activity | protein dimerization activity | calcium channel inhibitor activity | drug binding | heat shock protein binding | SMAD binding | heterocyclic compound binding | macrolide binding

GO Biological Process

regulation of activin receptor signaling pathway | negative regulation of phosphorylation | ventricular cardiac muscle tissue morphogenesis | regulation of dephosphorylation | response to cytokine | regulation of cellular localization | muscle tissue development | calcium ion transmembrane import into cytosol | cytosolic calcium ion transport | regulation of localization | heart trabecula morphogenesis | peptidyl-amino acid modification | establishment of localization | regulation of immune system process | negative regulation of cellular process | regulation of phosphatase activity | response to metal ion | response to drug | negative regulation of protein phosphorylation | cellular chemical homeostasis | cellular process | channel regulator activity | localization | cellular homeostasis | chaperone-mediated protein folding | regulation of calcium-mediated signaling | heart morphogenesis | negative regulation of signaling | metal ion transport | peptidyl-proline modification | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | regulation of binding | muscle structure development | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of metabolic process | regulation of cytosolic calcium ion concentration | trabecula morphogenesis | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | cellular component organization | negative regulation of calcium-mediated signaling | calcium ion homeostasis | positive regulation of protein binding | T cell activation | calcium ion transport into cytosol | muscle contraction | muscle organ morphogenesis | response to stimulus | ion channel inhibitor activity | positive regulation of protein metabolic process | mononuclear cell proliferation | heart trabecula formation | regulation of protein ubiquitination | cardiac muscle tissue development | muscle tissue morphogenesis | supramolecular fiber organization | negative regulation of transporter activity | cellular localization | divalent metal ion transport | cardiac ventricle morphogenesis | negative regulation of transport | negative regulation of metabolic process | cellular component assembly | protein modification process | response to iron ion | macromolecule modification | negative regulation of calcium ion transmembrane transport | negative regulation of transmembrane transport | molecular function regulator | metal ion homeostasis | response to nitrogen compound | regulation of calcium ion transport into cytosol | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | channel inhibitor activity | multicellular organism development | negative regulation of catalytic activity | calcium ion transmembrane transport | response to purine-containing compound | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | amyloid fibril formation | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | negative regulation of release of sequestered calcium ion into cytosol | cytokine-mediated signaling pathway | regulation of release of sequestered calcium ion into cytosol | negative regulation of ion transmembrane transport | cellular response to cytokine stimulus | cell proliferation | leukocyte proliferation | negative regulation of calcium ion transmembrane transporter activity | negative regulation of sequestering of calcium ion | regulation of cellular protein metabolic process | peptidyl-prolyl cis-trans isomerase activity | negative regulation of ion transport | cellular protein-containing complex assembly | regulation of calcium ion transmembrane transport | response to xenobiotic stimulus | regulation of amyloid precursor protein catabolic process | cation homeostasis | negative regulation of protein dephosphorylation | striated muscle tissue development | cellular cation homeostasis | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | negative regulation of cation channel activity | positive regulation of sequestering of calcium ion | negative regulation of calcium ion transport | regulation of protein metabolic process | heart development | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | negative regulation of calcium ion transport into cytosol | lymphocyte activation | positive regulation of molecular function | release of sequestered calcium ion into cytosol | regulation of ryanodine-sensitive calcium-release channel activity | cation transmembrane transport | calcium channel regulator activity | protein-containing complex assembly | protein metabolic process | cardiac ventricle development | positive regulation of protein modification process | response to organic substance | SMAD protein complex assembly | tissue morphogenesis | regulation of protein dephosphorylation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | ventricular cardiac muscle tissue development | anatomical structure development | cell surface receptor signaling pathway | metabolic process | chemical homeostasis | calcium ion transport | response to caffeine | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | regulation of sequestering of calcium ion | protein folding | animal organ development | negative regulation of cellular protein metabolic process | T cell proliferation | ion homeostasis | regulation of phosphate metabolic process | inorganic cation transmembrane transport | response to alkaloid | regulation of ion transmembrane transport | positive regulation of binding | cell activation | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | lymphocyte proliferation | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | transmembrane transport | signaling | regulation of protein binding | response to organic cyclic compound | calcium channel inhibitor activity | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | cellular protein metabolic process | negative regulation of phosphoprotein phosphatase activity | anatomical structure morphogenesis | cation transport | regulation of ion transport | regulation of phosphoprotein phosphatase activity | developmental process | negative regulation of ryanodine-sensitive calcium-release channel activity | regulation of calcium ion transport | cellular protein modification process | regulation of transport | regulation of cation channel activity | response to organonitrogen compound | cellular metal ion homeostasis | negative regulation of dephosphorylation | cardiac chamber development | negative regulation of hydrolase activity | positive regulation of metabolic process | regulation of calcium ion transmembrane transporter activity | ion transport | protein peptidyl-prolyl isomerization | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | circulatory system development | divalent inorganic cation homeostasis | positive regulation of protein ubiquitination | muscle organ development | muscle system process | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

supramolecular fiber | integral component of membrane | sarcoplasmic reticulum | intracellular membrane-bounded organelle | synapse | extrinsic component of organelle membrane | neuron projection | extrinsic component of membrane | organelle membrane | sarcomere | voltage-gated calcium channel complex | cell | cytoplasmic side of membrane | plasma membrane protein complex | distal axon | intrinsic component of membrane | myofibril | cytoplasm | intracellular organelle | endoplasmic reticulum | contractile fiber | presynapse | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | endomembrane system | endoplasmic reticulum membrane | plasma membrane | ryanodine receptor complex | calcium channel complex | membrane-bounded organelle | sarcoplasmic reticulum membrane | organelle | I band | axon terminus | sarcoplasm | cell periphery | axon | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | Z disc | cytosol | intracellular | membrane | supramolecular complex