QuickView for FURIN;jsessionid=323503F8762482E756D71121B0FD6109;jsessionid=8145269ECF4D320CCE65742490541A3D (gene)

Gene Symbol:

Furin Mus musculus

Full name:

furin (paired basic amino acid cleaving enzyme)

Synonyms:

9130404I01Rik, Fur, PACE, Pcsk3, SPC1, furin, dibasic-processing enzyme, paired basic amino acid residue cleaving enzyme, prohormone convertase 3, proprotein convertase subtilisin/kexin type 3, subtilisin pro-protein processing enzyme

Genomic Location:

Chr 7: 87534080-87550317

Description:

This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stag...

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This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ELK1_01 ,  P300_01 ,  GATA1_02 ,  GATA1_03 ,  LYF1_01 ,  ETS1_B ,  ETS2_B ,  VDR_Q3 ,  NERF_Q2 ,  TEL2_Q6 ,  ETS_Q4 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  CACTGTG_MIR128A_MIR128B ,  CACTTTG_MIR520G_MIR520H ,  ATGCTGC_MIR103_MIR107 ,  GTGCCTT_MIR506 ,  CTATGCA_MIR153 ,  AGGGCAG_MIR18A ,  CTGAGCC_MIR24 ,  GTAAGAT_MIR200A ,  GGCAGCT_MIR22 ,  CCATCCA_MIR432 ,  CTCCAAG_MIR432 ,  AAGCAAT_MIR137 ,  ACCAAAG_MIR9 ,  GACAATC_MIR219 ,  CCAGGGG_MIR331 ,  GGCACTT_MIR519E ,  TGCAAAC_MIR452 ,  TAAYNRNNTCC_UNKNOWN ,  YCATTAA_UNKNOWN ,  YTTCCNNNGGAMR_UNKNOWN ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  MGGAAGTG_GABP_B ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-452 ,  Predicted Gene Targets for miR-543

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