QuickView for GCLC;jsessionid=9458CF7126141EC75D74CCC3AA559853;jsessionid=5CA591CF9359CF3616ABBADB5C723DF9;jsessionid=B09B4AA267BEB89BF91FF2003BF8F7BA;jsessionid=F27062248440544319E969D80EEC7D57 (gene)
- Gene Symbol:
- GSH1
Saccharomyces cerevisiae - Full name:
- Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury
- Synonyms:
- GSH1, GSH1, Gsh1, GSH1, YJL101C
- Genomic Location:
- Chr X: 234316-236352
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
glutamate-cysteine ligase activity | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | acid-amino acid ligase activity | catalytic activity | ATP binding | ligase activity, forming carbon-nitrogen bonds | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | ligase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding
GO Biological Process
sulfur compound metabolic process | glutathione metabolic process | response to metal ion | response to drug | response to antibiotic | cellular process | response to inorganic substance | response to hydrogen peroxide | response to stimulus | peptide biosynthetic process | response to stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cofactor metabolic process | cellular biosynthetic process | nitrogen compound metabolic process | cofactor biosynthetic process | cellular amide metabolic process | response to oxidative stress | biosynthetic process | response to cadmium ion | response to toxic substance | peptide metabolic process | glutathione biosynthetic process | metabolic process | organic substance metabolic process | response to reactive oxygen species | amide biosynthetic process | cellular modified amino acid metabolic process | cellular metabolic process
GO Cellular Component
catalytic complex | cell | cytoplasm | protein-containing complex | glutamate-cysteine ligase complex | intracellular
