QuickView for GRIN2B;jsessionid=C12A10A58E3870B513588554607B125B;jsessionid=0575FD66BB470ADE82EFB7272DE8AB40;jsessionid=1BCF475DCC9BD4F0BF70E71475BA0620 (gene)
- Gene Symbol:
- Grin2b
Rattus norvegicus - Full name:
- glutamate ionotropic receptor NMDA type subunit 2B
- Synonyms:
- GluN2B, glutamate receptor ionotropic, NMDA 2B, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, glutamate [NMDA] receptor subunit epsilon-2, glutamate receptor, ionotropic, N-methyl D-aspartate 2B, glutamate receptor, ionotropic, NMDA2B
- Genomic Location:
- Chr 4: 172721895-173183187
- Description:
-
subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AAANWWTGC_UNKNOWN , AAAYRNCTG_UNKNOWN , EVI1_06 , RSRFC4_01 , YY1_01 , GATA1_01 , IK1_01 , IK2_01 , IK3_01 , GATA1_03
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
transmitter-gated ion channel activity | beta-catenin binding | ligand-gated calcium channel activity | neurotransmitter receptor activity | glycine binding | voltage-gated ion channel activity | cation binding | passive transmembrane transporter activity | neurotransmitter binding | transmembrane signaling receptor activity | carboxylic acid binding | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | signaling receptor binding | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | cytokine receptor binding | anion binding | amino acid binding | NMDA glutamate receptor activity | cation transmembrane transporter activity | dopamine receptor binding | signaling receptor activity | D2 dopamine receptor binding | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | protein heterodimerization activity | scaffold protein binding | extracellular ligand-gated ion channel activity | glutamate receptor activity | ion binding | cell adhesion molecule binding | protein binding | zinc ion binding | ionotropic glutamate receptor activity | metal ion transmembrane transporter activity | protein dimerization activity | interleukin-1 receptor binding | voltage-gated cation channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | G-protein coupled receptor binding | excitatory extracellular ligand-gated ion channel activity | extracellularly glutamate-gated ion channel activity | glutamate binding | transition metal ion binding | cation channel activity | glutamate-gated calcium ion channel activity | inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | growth factor receptor binding | drug binding | calcium channel activity | organic acid binding | metal ion binding | ion channel activity | substrate-specific channel activity | glutamate receptor binding | ionotropic glutamate receptor binding | small molecule binding
GO Biological Process
transmitter-gated ion channel activity | response to extracellular stimulus | behavioral response to pain | brain development | regulation of cysteine-type endopeptidase activity | response to nutrient levels | detection of stimulus | protein heterotetramerization | long-term memory | response to cytokine | behavioral fear response | intracellular signal transduction | calcium ion transmembrane import into cytosol | cytosolic calcium ion transport | regulation of localization | ligand-gated calcium channel activity | hippocampus development | establishment of localization | response to hormone | negative regulation of cellular process | response to metal ion | excitatory postsynaptic potential | detection of mechanical stimulus involved in sensory perception | defense response | nervous system development | cellular response to extracellular stimulus | response to growth hormone | response to drug | cellular chemical homeostasis | NMDA selective glutamate receptor signaling pathway | voltage-gated ion channel activity | cellular response to ether | response to antibiotic | sensory perception of mechanical stimulus | regulation of neuron death | cellular process | response to magnesium ion | localization | cellular homeostasis | positive regulation of synaptic transmission | passive transmembrane transporter activity | metal ion transport | negative regulation of synapse organization | chemical synaptic transmission | regulation of neuronal synaptic plasticity | learning | macromolecule localization | response to hypoxia | cellular response to starvation | regulation of proteolysis | response to corticosterone | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | response to peptide hormone | regulation of cellular process | cellular response to lipid | regulation of metabolic process | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | response to ether | positive regulation of cellular protein metabolic process | ligand-gated ion channel activity | cellular response to organonitrogen compound | cellular component organization | calcium ion homeostasis | cellular response to metal ion | head development | calcium ion transport into cytosol | associative learning | response to stimulus | ion gated channel activity | regulation of long-term synaptic potentiation | response to pain | positive regulation of protein metabolic process | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | positive regulation of peptidase activity | response to cocaine | response to stress | response to peptide | positive regulation of cysteine-type endopeptidase activity | positive regulation of long-term synaptic potentiation | response to starvation | receptor clustering | cellular response to inorganic substance | cellular localization | divalent metal ion transport | response to alcohol | cellular response to corticosterone stimulus | rhythmic process | positive regulation of proteolysis | cellular response to organic cyclic compound | cellular component assembly | regulation of synapse structure or activity | modulation of chemical synaptic transmission | embryo development | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | cellular response to forskolin | response to ethanol | negative regulation of dendritic spine maintenance | regulation of membrane potential | detection of abiotic stimulus | response to nitrogen compound | regulation of long-term neuronal synaptic plasticity | cellular response to hormone stimulus | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | regulation of signal transduction | cellular response to antibiotic | multicellular organism development | regulation of peptidase activity | calcium ion transmembrane transport | regulation of MAPK cascade | response to amino acid | learning or memory | response to dsRNA | positive regulation of glutamate secretion | protein complex oligomerization | response to methylmercury | regulation of catalytic activity | regulation of phosphorylation | ion transmembrane transport | localization within membrane | nonassociative learning | telencephalon development | detection of mechanical stimulus involved in sensory perception of pain | regulation of postsynaptic membrane potential | protein localization to membrane | positive regulation of secretion | response to ketone | cellular response to stress | response to lipid | nervous system process | synaptic signaling | NMDA glutamate receptor activity | cation transmembrane transporter activity | positive regulation of cellular metabolic process | cellular ion homeostasis | response to manganese ion | response to ammonium ion | regulation of synapse organization | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | cellular response to curcumin | response to corticosteroid | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | positive regulation of hydrolase activity | second-messenger-mediated signaling | cognition | sensory perception of pain | regulation of cellular protein metabolic process | extracellular ligand-gated ion channel activity | cellular response to glucocorticoid stimulus | positive regulation of endopeptidase activity | positive regulation of neuron death | startle response | protein tetramerization | response to toxic substance | regulation of glutamate secretion | response to xenobiotic stimulus | cellular response to amino acid stimulus | cation homeostasis | cellular response to corticosteroid stimulus | sensory organ development | cellular response to drug | chordate embryonic development | response to curcumin | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | cellular calcium ion homeostasis | cellular response to dsRNA | homeostatic process | limbic system development | regulation of protein phosphorylation | suckling behavior | embryo development ending in birth or egg hatching | positive regulation of transport | cerebral cortex development | cellular response to magnesium starvation | cellular response to mineralocorticoid stimulus | positive regulation of molecular function | calcium-mediated signaling | cation transmembrane transport | protein-containing complex assembly | multicellular organismal response to stress | fear response | response to organic substance | negative regulation of cell projection organization | ionotropic glutamate receptor activity | response to antineoplastic agent | response to mechanical stimulus | detection of stimulus involved in sensory perception | metal ion transmembrane transporter activity | regulation of intracellular signal transduction | anatomical structure development | response to amine | cell surface receptor signaling pathway | voltage-gated cation channel activity | neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | regulation of postsynaptic cytosolic calcium ion concentration | response to mineralocorticoid | cellular protein localization | chemical homeostasis | calcium ion transport | regulation of secretion | behavior | positive regulation of cell death | positive regulation of amino acid transport | animal organ development | positive regulation of ion transport | forebrain development | excitatory extracellular ligand-gated ion channel activity | pallium development | extracellularly glutamate-gated ion channel activity | ion homeostasis | regulation of phosphate metabolic process | inorganic cation transmembrane transport | response to alkaloid | regulation of dendritic spine maintenance | cellular response to steroid hormone stimulus | detection of mechanical stimulus | positive regulation of organic acid transport | regulation of postsynapse organization | regulation of protein kinase A signaling | cation channel activity | memory | sensory perception | response to fungicide | regulation of cell communication | transmembrane transport | action potential | glutamate-gated calcium ion channel activity | signaling | feeding behavior | inorganic cation transmembrane transporter activity | response to organic cyclic compound | neuromuscular process | protein localization | voltage-gated channel activity | protein heterooligomerization | regulation of endopeptidase activity | cation transport | cellular macromolecule localization | channel activity | glutamate receptor signaling pathway | response to biotic stimulus | regulation of ion transport | developmental process | calcium channel activity | positive regulation of anion transport | behavioral defense response | sensitization | cellular response to manganese ion | regulation of transport | response to organonitrogen compound | cellular metal ion homeostasis | response to electrical stimulus | regulation of anion transport | response to calcium ion | central nervous system development | ion channel activity | response to anesthetic | in utero embryonic development | positive regulation of metabolic process | regulation of synaptic plasticity | response to amphetamine | ion transport | regulation of cell projection organization | long-term synaptic potentiation | cellular response to organic substance | regulation of cell death | response to carbohydrate | response to steroid hormone | ionotropic glutamate receptor signaling pathway | divalent inorganic cation homeostasis | substrate-specific channel activity | regulation of cellular component organization | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | response to glucocorticoid | cellular response to growth factor stimulus | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
presynaptic membrane | supramolecular fiber | synaptic cleft | dendritic spine | exocytic vesicle | integral component of membrane | dendrite | synapse | neuron projection | somatodendritic compartment | sarcomere | postsynaptic specialization membrane | cytoplasmic vesicle | cell body | cell | neuronal cell body | plasma membrane protein complex | distal axon | intrinsic component of membrane | synaptic membrane | terminal bouton | myofibril | cytoplasm | intracellular organelle | NMDA selective glutamate receptor complex | receptor complex | dendritic tree | contractile fiber | presynapse | protein-containing complex | cell projection | secretory vesicle | postsynaptic membrane | endomembrane system | neuron spine | postsynapse | plasma membrane | postsynaptic density membrane | vesicle | transport vesicle | postsynaptic density | asymmetric synapse | integral component of plasma membrane | synaptic vesicle | extracellular region | membrane-bounded organelle | organelle | postsynaptic specialization | I band | axon terminus | apical dendrite | cell periphery | axon | ionotropic glutamate receptor complex | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | Z disc | intracellular vesicle | cell surface | intracellular | cell junction | membrane | supramolecular complex | intrinsic component of plasma membrane
