QuickView for HDAC3;jsessionid=D996798873EDBDFBB19A261C85A1B879;jsessionid=0C60B8E77A5B86F5B4ED71F7F3D10F40 (gene)
- Gene Symbol:
- Hdac3
Rattus norvegicus - Full name:
- histone deacetylase 3
- Synonyms:
- histone deacetylase 3, HD3
- Genomic Location:
- Chr 18: 30857209-30875986
- Description:
-
mouse homolog plays an important role in regulating cell cycle progression
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
NF-kappaB binding | GTPase binding | cyclin binding | cation binding | histone deacetylase activity (H3-K14 specific) | enzyme binding | nucleic acid binding | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | histone deacetylase activity | DNA binding | transcription corepressor activity | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | protein binding | transcription factor binding | chromatin DNA binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | histone deacetylase binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | response to extracellular stimulus | maintenance of protein location in nucleus | negative regulation of JNK cascade | negative regulation of phosphorylation | negative regulation of intracellular transport | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | negative regulation of MAPK cascade | regulation of cellular localization | positive regulation of apoptotic process | regulation of localization | regulation of programmed cell death | regulation of cardiac muscle cell differentiation | response to hormone | negative regulation of cellular process | response to dexamethasone | negative regulation of RNA biosynthetic process | histone modification | microtubule cytoskeleton organization | regulation of protein import | response to drug | negative regulation of protein phosphorylation | histone deacetylation | positive regulation of phosphate metabolic process | microtubule-based process | regulation of neuron death | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | negative regulation of muscle organ development | circadian regulation of gene expression | localization | chromatin organization | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | macromolecule localization | regulation of cell cycle | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | histone deacetylase activity (H3-K14 specific) | positive regulation of epithelial cell apoptotic process | spindle assembly | regulation of protein export from nucleus | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of myotube differentiation | regulation of cellular process | negative regulation of interleukin-1 production | negative regulation of cardiocyte differentiation | regulation of apoptotic process | regulation of metabolic process | negative regulation of tumor necrosis factor production | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | negative regulation of cardiac muscle tissue development | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | cellular response to mechanical stimulus | positive regulation of protein metabolic process | negative regulation of striated muscle cell differentiation | NAD-dependent histone deacetylase activity (H3-K14 specific) | negative regulation of intracellular protein transport | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | protein localization to nucleus | circadian rhythm | cellular localization | rhythmic process | cellular nitrogen compound metabolic process | maintenance of protein localization in organelle | positive regulation of type B pancreatic cell apoptotic process | negative regulation of transport | negative regulation of muscle tissue development | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | protein deacetylase activity | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | cellular response to parathyroid hormone stimulus | histone H3 deacetylation | regulation of TOR signaling | regulation of intracellular transport | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | organelle assembly | cellular response to hormone stimulus | nitrogen compound metabolic process | regulation of signal transduction | regulation of protein stability | negative regulation of phosphate metabolic process | NAD-dependent protein deacetylase activity | regulation of MAPK cascade | regulation of phosphorylation | negative regulation of cellular protein localization | regulation of gene expression | histone deacetylase activity | response to ketone | cellular response to stress | response to lipid | cell cycle | negative regulation of cardiac muscle cell differentiation | positive regulation of intracellular protein transport | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of protein localization to nucleus | histone H4-K12 deacetylation | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | response to corticosteroid | cellular response to fluid shear stress | transcription corepressor activity | regulation of transcription by RNA polymerase II | protein localization to organelle | positive regulation of protein localization to nucleus | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of stress-activated MAPK cascade | positive regulation of neuron death | response to parathyroid hormone | negative regulation of protein export from nucleus | response to xenobiotic stimulus | regulation of epithelial cell apoptotic process | regulation of tumor necrosis factor production | negative regulation of myotube differentiation | NAD-dependent histone deacetylase activity | maintenance of protein location | regulation of interleukin-1 production | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | negative regulation of striated muscle tissue development | positive regulation of TOR signaling | positive regulation of establishment of protein localization | regulation of protein phosphorylation | histone H4 deacetylation | regulation of RNA metabolic process | positive regulation of transport | regulation of mitotic cell cycle | regulation of nucleocytoplasmic transport | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of cardiac muscle tissue development | regulation of protein import into nucleus | response to antineoplastic agent | response to mechanical stimulus | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | positive regulation of neuron apoptotic process | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | positive regulation of programmed cell death | maintenance of protein location in cell | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | cytoskeleton organization | transcription, DNA-templated | positive regulation of intracellular transport | regulation of JNK cascade | positive regulation of protein transport | negative regulation of protein metabolic process | response to fluid shear stress | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of developmental growth | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule localization | cellular macromolecule biosynthetic process | positive regulation of protein import into nucleus | regulation of developmental process | organelle organization | regulation of muscle cell differentiation | positive regulation of protein import | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | negative regulation of muscle cell differentiation | positive regulation of metabolic process | chromosome organization | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to steroid hormone | spindle organization | positive regulation of nucleocytoplasmic transport | negative regulation of cell differentiation | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | regulation of muscle organ development | macromolecule metabolic process | maintenance of location in cell | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | microtubule | cytoplasm | spindle | intracellular organelle | Golgi apparatus | protein-containing complex | endomembrane system | nucleoplasm | plasma membrane | chromatin | microtubule cytoskeleton | spindle microtubule | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex
