QuickView for Hif-1a;jsessionid=98E78F8D57293491000D013BE664D6F3;jsessionid=2C895902792A07DC05D70581D19A4C7B (gene)
- Gene Symbol:
- HIF1A
Canis lupus familiaris - Full name:
- hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- Synonyms:
- N/A
- Genomic Location:
- Chr 8: 39643254-39685890
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
AACTTT_UNKNOWN , HEN1_01 , MYCMAX_02 , NFY_01 , CCCNNNNNNAAGWT_UNKNOWN , AREB6_01 , TGIF_01 , HIF1_Q5 , AP2ALPHA_01 , AP2GAMMA_01
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | hormone receptor binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein domain specific binding | ubiquitin-like protein ligase binding | RNA polymerase II regulatory region DNA binding | p53 binding | E-box binding | DNA binding | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | histone acetyltransferase binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | ubiquitin protein ligase binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | Hsp90 protein binding | heat shock protein binding | histone deacetylase binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | leukocyte homeostasis | negative regulation of TOR signaling | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | positive regulation of erythrocyte differentiation | brain development | positive regulation of insulin secretion involved in cellular response to glucose stimulus | response to radiation | positive regulation of hormone biosynthetic process | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | microtubule-based transport | response to cytokine | response to interleukin-1 | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | cell motility | regulation of neurogenesis | developmental process involved in reproduction | regulation of cellular localization | oxygen homeostasis | regulation of cell development | regulation of localization | morphogenesis of an epithelium | regulation of carbohydrate metabolic process | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | eye development | establishment of localization | regulation of aerobic respiration | regulation of autophagy | regulation of immune system process | negative regulation of neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | response to metal ion | cell differentiation | defense response | nervous system development | epithelial to mesenchymal transition | cellular chemical homeostasis | neurogenesis | glucose homeostasis | elastin metabolic process | regulation of organelle organization | positive regulation of cellular component movement | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | mesenchyme development | intracellular transport | regulation of neuroblast proliferation | microtubule-based process | positive regulation of vascular endothelial growth factor receptor signaling pathway | blood vessel morphogenesis | pattern specification process | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | secretion | negative regulation of oxidative stress-induced neuron death | establishment of organelle localization | regulation of cell motility | localization | cellular homeostasis | regulation of glycolytic process | epithelial tube morphogenesis | cell maturation | tissue remodeling | heart morphogenesis | negative regulation of signaling | visual learning | determination of left/right symmetry | reproductive system development | regulation of vascular endothelial growth factor receptor signaling pathway | immune system development | learning | negative regulation of apoptotic process | digestive tract morphogenesis | response to hypoxia | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of bone mineralization | tissue development | regulation of cell differentiation | anatomical structure homeostasis | cytoskeleton-dependent intracellular transport | regulation of lymphocyte apoptotic process | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organelle localization | organic cyclic compound metabolic process | RNA biosynthetic process | negative regulation of oxidative stress-induced cell death | epithelium development | neural fold formation | cellular aromatic compound metabolic process | positive regulation of epithelial cell migration | negative regulation of biomineral tissue development | positive regulation of autophagy of mitochondrion | head development | epithelial cell differentiation involved in mammary gland alveolus development | regulation of peptide secretion | associative learning | regulation of vasculature development | response to stimulus | vasculature development | negative regulation of T cell apoptotic process | mesenchymal cell development | monocarboxylic acid metabolic process | regulation of insulin secretion | embryonic epithelial tube formation | positive regulation of immune system process | determination of heart left/right asymmetry | cellular response to hypoxia | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | organelle transport along microtubule | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of neuroblast proliferation | tube morphogenesis | epithelial cell development | epithelial tube formation | microtubule-based movement | reproduction | cellular localization | positive regulation of vascular endothelial growth factor production | cardiovascular system development | cardiac ventricle morphogenesis | cellular nitrogen compound metabolic process | positive regulation of hormone secretion | regulation of macroautophagy | positive regulation of blood vessel endothelial cell migration | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | cartilage development | intestinal epithelial cell development | regulation of peptide transport | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | cellular biosynthetic process | embryo development | response to iron ion | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | mitochondrion transport along microtubule | regulation of TOR signaling | metal ion homeostasis | positive regulation of mitochondrion organization | embryonic placenta development | blood vessel development | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | negative regulation of neuron apoptotic process | response to light stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of growth | multicellular organism development | response to activity | cell migration | inflammatory response to wounding | learning or memory | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | mammary gland development | regulation of catalytic activity | regulation of insulin secretion involved in cellular response to glucose stimulus | embryonic hemopoiesis | cellular response to oxidative stress | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of hormone levels | regulation of hormone secretion | regulation of ossification | connective tissue replacement involved in inflammatory response wound healing | wound healing | telencephalon development | determination of bilateral symmetry | mammary gland lobule development | regulation of gene expression | positive regulation of secretion | outflow tract morphogenesis | cellular response to stress | nervous system process | regulation of stem cell proliferation | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | cellular ion homeostasis | animal organ morphogenesis | regulation of pri-miRNA transcription by RNA polymerase II | negative regulation of lymphocyte apoptotic process | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | neural tube formation | hemoglobin biosynthetic process | regulation of cellular component movement | regulation of transcription by RNA polymerase II | morphogenesis of an epithelial fold | response to oxidative stress | B cell homeostasis | positive regulation of cell differentiation | regulation of endothelial cell migration | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | positive regulation of myeloid cell differentiation | cognition | homeostasis of number of cells | stem cell differentiation | mitochondrion localization | positive regulation of cell migration | cellular response to cytokine stimulus | biosynthetic process | neural tube development | regulation of hormone metabolic process | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | muscle cell cellular homeostasis | angiogenesis | positive regulation of pri-miRNA transcription by RNA polymerase II | digestive tract development | heart looping | regulation of apoptotic signaling pathway | cation homeostasis | sensory organ development | regulation of mitochondrion organization | neural crest cell migration | chordate embryonic development | epithelial cell maturation | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | eye morphogenesis | regulation of neuron apoptotic process | lymphocyte homeostasis | regulation of T cell apoptotic process | inflammatory response | positive regulation of signal transduction | heart development | homeostatic process | neural fold elevation formation | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of locomotion | embryo development ending in birth or egg hatching | iron ion homeostasis | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | cerebral cortex development | intestinal epithelial cell differentiation | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | hypoxia-inducible factor-1alpha signaling pathway | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | wound healing involved in inflammatory response | carboxylic acid metabolic process | regulation of autophagy of mitochondrion | negative regulation of thymocyte apoptotic process | neuron differentiation | cytokine production | embryonic organ morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | cardiac ventricle development | regulation of growth | response to organic substance | gland development | positive regulation of insulin secretion | tissue morphogenesis | visual behavior | digestive system development | regulation of hemopoiesis | regulation of cellular respiration | negative regulation of bone mineralization | retina development in camera-type eye | establishment of mitochondrion localization, microtubule-mediated | lactation | response to wounding | establishment of mitochondrion localization | negative regulation of ossification | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | embryonic heart tube development | anatomical structure development | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | metabolic process | positive regulation of cell development | negative regulation of response to oxidative stress | regulation of receptor biosynthetic process | mesenchymal cell differentiation | regulation of DNA-templated transcription in response to stress | regulation of thymocyte apoptotic process | regulation of RNA biosynthetic process | developmental maturation | regulation of body fluid levels | negative regulation of programmed cell death | embryonic organ development | transport along microtubule | regulation of erythrocyte differentiation | chemical homeostasis | regulation of secretion | behavior | body fluid secretion | morphogenesis of embryonic epithelium | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | negative regulation of mesenchymal cell apoptotic process | organic substance metabolic process | connective tissue development | vascular endothelial growth factor production | negative regulation of intrinsic apoptotic signaling pathway | lactate metabolic process | negative regulation of gene expression | animal organ development | forebrain development | pallium development | gene expression | regulation of protein secretion | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | ion homeostasis | regulation of ATP metabolic process | regulation of phosphate metabolic process | mammary gland epithelium development | regulation of transforming growth factor beta2 production | cellular iron ion homeostasis | positive regulation of autophagy | transcription, DNA-templated | positive regulation of cytokine production | dopaminergic neuron differentiation | positive regulation of macroautophagy | positive regulation of endothelial cell migration | stem cell development | positive regulation of protein transport | camera-type eye development | mammary gland alveolus development | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of cell communication | axo-dendritic transport | regulation of blood vessel endothelial cell migration | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | organic acid metabolic process | negative regulation of leukocyte apoptotic process | regulation of transcription from RNA polymerase II promoter in response to stress | regulation of cytokine production | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of stem cell proliferation | camera-type eye morphogenesis | collagen metabolic process | reproductive structure development | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | axonal transport of mitochondrion | cellular response to interleukin-1 | columnar/cuboidal epithelial cell development | tube development | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | hemoglobin metabolic process | positive regulation of nucleic acid-templated transcription | neural crest cell differentiation | cellular metal ion homeostasis | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | cardiac chamber development | heterocycle metabolic process | regulation of vascular endothelial growth factor production | intestinal epithelial cell maturation | tube formation | mammary gland epithelial cell differentiation | central nervous system development | regulation of generation of precursor metabolites and energy | in utero embryonic development | positive regulation of metabolic process | retina vasculature development in camera-type eye | transition metal ion homeostasis | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | positive regulation of receptor biosynthetic process | placenta development | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | carbohydrate homeostasis | glycoprotein metabolic process | B-1 B cell homeostasis | neural crest cell development | positive regulation of angiogenesis | regulation of cellular component organization | axonal transport | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | signal transduction | regulation of signaling | response to muscle activity | positive regulation of gene expression | regulation of hormone biosynthetic process | iris morphogenesis | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
nuclear transcription factor complex | intracellular membrane-bounded organelle | neuron projection | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | motile cilium | nuclear body | protein-containing complex | cell projection | nucleoplasm | plasma membrane bounded cell projection cytoplasm | cilium | nuclear speck | cytoplasmic region | membrane-bounded organelle | nucleus | organelle | axon cytoplasm | axon | membrane-enclosed lumen | cytosol | intracellular
