QuickView for Hspa5;jsessionid=C1144D6B1B9207F271A23997F1BA1607 (gene)
- Gene Symbol:
- KAR2
Saccharomyces cerevisiae - Full name:
- ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
- Synonyms:
- GRP78, KAR2, YJL034W
- Genomic Location:
- Chr X: 381322-383370
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | unfolded protein binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ion binding | organic cyclic compound binding | protein binding involved in protein folding | purine ribonucleoside triphosphate binding | protein binding | misfolded protein binding | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding
GO Biological Process
nucleus organization | response to endoplasmic reticulum stress | fungal-type cell wall biogenesis | 'de novo' posttranslational protein folding | proteolysis | organelle fusion | establishment of localization | protein targeting to ER | SRP-dependent cotranslational protein targeting to membrane | intracellular transport | posttranslational protein targeting to endoplasmic reticulum membrane | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | chaperone-mediated protein folding | protein transport | karyogamy | protein localization to endoplasmic reticulum | macromolecule localization | endoplasmic reticulum unfolded protein response | establishment of localization in cell | cellular polysaccharide biosynthetic process | regulation of cellular process | catabolic process | cellular response to unfolded protein | response to topologically incorrect protein | cotranslational protein targeting to membrane | cellular component organization | cellular response to topologically incorrect protein | response to stimulus | fungal-type cell wall polysaccharide biosynthetic process | fungal-type cell wall beta-glucan metabolic process | response to stress | intracellular protein transport | cellular polysaccharide metabolic process | polysaccharide metabolic process | SRP-dependent cotranslational protein targeting to membrane, translocation | reproduction | cellular protein catabolic process | posttranslational protein targeting to membrane, translocation | cellular localization | response to temperature stimulus | proteasomal protein catabolic process | conjugation | cellular biosynthetic process | beta-glucan biosynthetic process | response to nitrogen compound | nitrogen compound metabolic process | reproductive process | polysaccharide biosynthetic process | protein localization to membrane | organic substance transport | cellular response to stress | protein catabolic process | cellular response to heat | karyogamy involved in conjugation with cellular fusion | cellular carbohydrate metabolic process | peptide transport | protein localization to organelle | carbohydrate biosynthetic process | biosynthetic process | 'de novo' protein folding | cell wall biogenesis | carbohydrate metabolic process | conjugation with cellular fusion | cell communication | protein binding involved in protein folding | proteasome-mediated ubiquitin-dependent protein catabolic process | ERAD pathway | establishment of protein localization to membrane | fungal-type cell wall polysaccharide metabolic process | fungal-type cell wall beta-glucan biosynthetic process | protein metabolic process | response to organic substance | cellular macromolecule catabolic process | establishment of protein localization to organelle | metabolic process | establishment of protein localization to endoplasmic reticulum | cellular protein localization | amide transport | glucan biosynthetic process | organic substance metabolic process | protein folding | response to heat | establishment of protein localization | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | transmembrane transport | fungal-type cell wall organization or biogenesis | signaling | intracellular protein transmembrane transport | protein localization | cellular protein metabolic process | response to unfolded protein | cellular macromolecule localization | cellular macromolecule biosynthetic process | chaperone cofactor-dependent protein refolding | protein targeting to membrane | organelle organization | cellular glucan metabolic process | response to organonitrogen compound | protein refolding | protein transmembrane transport | ubiquitin-dependent ERAD pathway | protein targeting | cellular metabolic process | cellular response to organic substance | modification-dependent protein catabolic process | sexual reproduction | signal transduction | macromolecule metabolic process
GO Cellular Component
endoplasmic reticulum chaperone complex | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | endoplasmic reticulum lumen | luminal surveillance complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular | membrane
