QuickView for IL7;jsessionid=644F8B3264E25E8D2F34659BFE8F09C9;jsessionid=82128F3626DEB704968ADAB30EFD9F37;jsessionid=EE0C8691E60E1491C425ECC08A5E38D5;jsessionid=638E65F11D504AD2F44E4C9E3EDEA8B1 (gene)
- Gene Symbol:
- IL7
Homo sapiens - Full name:
- interleukin 7
- Synonyms:
- IL-7, interleukin-7
- Genomic Location:
- Chr 8: 79807560-79880313
- Description:
-
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell developmen...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
PBX1_02 , GATA_Q6 , GATA_C , EVI1_03 , GGGYGTGNY_UNKNOWN , CAGGTG_E12_Q6 , EVI1_02 , EVI1_05 , AREB6_01 , GATA6_01
- Cytogenetic Map:
-
8q21.13
| Transcripts Names |
|---|
| NM_000880 |
| NM_001199886 |
| NM_001199887 |
| NM_001199888 |
| XM_011517522 |
| XM_017013397 |
| XM_011517523 |
GO Molecular Function
interleukin-7 receptor binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | protein binding | receptor regulator activity | growth factor activity | receptor ligand activity | cytokine activity | growth factor receptor binding
GO Biological Process
regulation of extrinsic apoptotic signaling pathway in absence of ligand | response to cytokine | regulation of B cell activation | homeostasis of number of cells within a tissue | regulation of programmed cell death | T cell lineage commitment | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | regulation of T cell differentiation | bone remodeling | positive regulation of cell adhesion | interleukin-7-mediated signaling pathway | tissue homeostasis | positive regulation of T cell differentiation | cellular process | lymphocyte differentiation | tissue remodeling | negative regulation of signaling | immune system development | regulation of response to cytokine stimulus | negative regulation of apoptotic process | regulation of cell differentiation | anatomical structure homeostasis | negative regulation of apoptotic signaling pathway | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of metabolic process | bone resorption | T cell activation | response to stimulus | positive regulation of immune system process | positive regulation of lymphocyte proliferation | regulation of cell proliferation | multicellular organismal homeostasis | positive regulation of cell-cell adhesion | positive regulation of B cell proliferation | positive regulation of cell activation | positive regulation of T cell activation | hemopoiesis | regulation of cell adhesion | cell-cell signaling | molecular function regulator | regulation of lymphocyte differentiation | leukocyte differentiation | positive regulation of response to cytokine stimulus | positive regulation of mononuclear cell proliferation | system development | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | positive regulation of lymphocyte differentiation | regulation of catalytic activity | regulation of T cell activation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | regulation of lymphocyte activation | animal organ morphogenesis | cytokine-mediated signaling pathway | positive regulation of cell differentiation | cellular response to interleukin-7 | negative regulation of extrinsic apoptotic signaling pathway | homeostasis of number of cells | cellular response to cytokine stimulus | positive regulation of chemokine production | regulation of apoptotic signaling pathway | cell communication | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | humoral immune response | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of cytokine-mediated signaling pathway | positive regulation of B cell activation | lymphocyte activation | T cell differentiation | regulation of signaling receptor activity | receptor regulator activity | positive regulation of organ growth | regulation of growth | response to organic substance | regulation of hemopoiesis | anatomical structure development | cell surface receptor signaling pathway | growth factor activity | cell fate commitment | positive regulation of leukocyte activation | negative regulation of programmed cell death | receptor ligand activity | immune response | cytokine activity | animal organ development | regulation of cell activation | positive regulation of cytokine production | cell activation | positive regulation of cytokine-mediated signaling pathway | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of developmental growth | regulation of cytokine production | anatomical structure morphogenesis | regulation of organ growth | regulation of developmental process | developmental process | regulation of chemokine production | regulation of B cell proliferation | regulation of cell-cell adhesion | immune system process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of cell death | negative regulation of cell death | positive regulation of leukocyte cell-cell adhesion | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process
