QuickView for Il1b;jsessionid=F9B5D7791542F1D3B261E9AB01198804;jsessionid=2B781EA3CD73B10A438A80BD40CA2568 (gene)
- Gene Symbol:
- IL1B
Canis lupus familiaris - Full name:
- interleukin 1, beta
- Synonyms:
- IL-1
- Genomic Location:
- Chr 17: 40130937-40135917
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
protein-containing complex binding | signaling receptor binding | cytokine receptor binding | molecular function regulator | protein domain specific binding | integrin binding | cell adhesion molecule binding | protein binding | receptor regulator activity | interleukin-1 receptor binding | receptor ligand activity | cytokine activity | growth factor receptor binding
GO Biological Process
positive regulation of immune response | response to extracellular stimulus | regulation of ERK1 and ERK2 cascade | regulation of T cell mediated immunity | negative regulation of phosphorylation | positive regulation of hormone biosynthetic process | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | negative regulation of cellular response to insulin stimulus | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | negative regulation of MAPK cascade | response to ATP | response to cytokine | positive regulation of cellular component organization | cell motility | response to lipopolysaccharide | developmental process involved in reproduction | negative regulation of peptide secretion | intracellular signal transduction | regulation of cell development | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | positive regulation of lipid catabolic process | regulation of immune system process | lipid storage | regulation of nitric oxide biosynthetic process | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | regulation of MAP kinase activity | positive regulation of lymphocyte activation | cell differentiation | regulation of vitamin metabolic process | defense response | positive regulation of protein catabolic process | response to drug | negative regulation of protein phosphorylation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | negative regulation of protein secretion | regulation of organelle organization | positive regulation of cellular component movement | regulation of peptide hormone secretion | positive regulation of protein secretion | regulation of lipid transport | response to organophosphorus | positive regulation of cellular biosynthetic process | cellular process | regulation of cytokine biosynthetic process | regulation of cell motility | localization | extrinsic apoptotic signaling pathway | negative regulation of signaling | positive regulation of immune effector process | positive regulation of reactive oxygen species metabolic process | positive regulation of adaptive immune response | positive regulation of epithelial to mesenchymal transition | positive regulation of heterotypic cell-cell adhesion | regulation of mitotic nuclear division | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of oxidoreductase activity | regulation of defense response to virus | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of cell division | granulocyte chemotaxis | negative regulation of hormone secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | positive regulation of interleukin-8 production | positive regulation of granulocyte macrophage colony-stimulating factor production | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | positive regulation of cellular protein metabolic process | positive regulation of T cell cytokine production | MAPK cascade | regulation of cell division | glycosaminoglycan biosynthetic process | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | regulation of vasculature development | response to stimulus | negative regulation of protein transport | positive regulation of NIK/NF-kappaB signaling | cellular response to mechanical stimulus | neutrophil chemotaxis | positive regulation of nitric oxide metabolic process | regulation of insulin secretion | positive regulation of immune system process | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | interleukin-1 beta production | leukocyte aggregation | response to stress | regulation of heterotypic cell-cell adhesion | positive regulation of chemokine biosynthetic process | negative regulation of protein kinase activity | positive regulation of lymphocyte proliferation | positive regulation of membrane protein ectodomain proteolysis | regulation of cell proliferation | positive regulation of lipid biosynthetic process | multicellular organismal homeostasis | negative regulation of glucose transmembrane transport | positive regulation of cell-cell adhesion | regulation of epithelial cell differentiation | programmed cell death | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | reproduction | positive regulation of vascular endothelial growth factor production | positive regulation of cytokine secretion | positive regulation of proteolysis | response to molecule of bacterial origin | positive regulation of T cell activation | negative regulation of transport | cellular response to organic cyclic compound | regulation of calcidiol 1-monooxygenase activity | regulation of phagocytosis | carbohydrate derivative biosynthetic process | regulation of protein transport | positive regulation of vitamin D biosynthetic process | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | regulation of steroid biosynthetic process | cellular biosynthetic process | macromolecule modification | regulation of steroid metabolic process | negative regulation of transmembrane transport | cell chemotaxis | activation of protein kinase activity | molecular function regulator | regulation of fever generation | leukocyte migration | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | monocyte aggregation | regulation of cellular response to stress | regulation of neurotransmitter levels | positive regulation of monooxygenase activity | locomotion | response to nitrogen compound | apoptotic process | protein kinase B signaling | regulation of interleukin-2 biosynthetic process | positive regulation of reactive oxygen species biosynthetic process | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | negative regulation of adiponectin secretion | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of secretion by cell | negative regulation of phosphate metabolic process | positive regulation of T-helper 1 cell cytokine production | positive regulation of icosanoid secretion | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | response to purine-containing compound | positive regulation of inflammatory response | negative regulation of lipid catabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | hyaluronan metabolic process | regulation of nitric-oxide synthase activity | regulation of acute inflammatory response | regulation of T cell activation | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | positive regulation of secretion | response to lipid | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | positive regulation of p38MAPK cascade | positive regulation of heat generation | regulation of nitrogen compound metabolic process | regulation of cell migration | positive regulation of JNK cascade | positive regulation of interleukin-2 biosynthetic process | small molecule metabolic process | regulation of interleukin-6 biosynthetic process | negative regulation of insulin receptor signaling pathway | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | negative regulation of protein serine/threonine kinase activity | regulation of cellular component movement | regulation of transcription by RNA polymerase II | response to nutrient | positive regulation of cell differentiation | acute-phase response | regulation of T cell cytokine production | negative regulation of extrinsic apoptotic signaling pathway | hyaluronan biosynthetic process | positive regulation of steroid metabolic process | positive regulation of cell migration | cellular response to cytokine stimulus | biosynthetic process | regulation of hormone metabolic process | regulation of cellular protein metabolic process | positive regulation of T cell proliferation | positive regulation of monocyte chemotactic protein-1 production | phosphorylation | interleukin-6 production | positive regulation of chemokine production | positive regulation of lipid localization | regulation of apoptotic signaling pathway | programmed cell death involved in cell development | protein phosphorylation | phosphate-containing compound metabolic process | cellular response to drug | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of lipid catabolic process | regulation of establishment of endothelial barrier | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | inflammatory response | regulation of cytokine production involved in immune response | regulation of endocrine process | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | leukocyte chemotaxis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | negative regulation of MAP kinase activity | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | positive regulation of myosin light chain kinase activity | positive regulation of transport | regulation of lipid biosynthetic process | apoptotic signaling pathway | fever generation | regulation of mitotic cell cycle | carboxylic acid metabolic process | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | cytokine production | regulation of signaling receptor activity | receptor regulator activity | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of kinase activity | response to mechanical stimulus | positive regulation of steroid biosynthetic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | positive regulation of calcidiol 1-monooxygenase activity | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | negative regulation of lipid metabolic process | metabolic process | lipid localization | regulation of protein catabolic process | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | regulation of vesicle-mediated transport | regulation of secretion | cell adhesion | receptor ligand activity | positive regulation of interleukin-6 production | immune response | cytokine activity | organic substance metabolic process | positive regulation of T-helper 1 type immune response | positive regulation of acute inflammatory response | cell death | regulation of glucose transmembrane transport | positive regulation of ion transport | regulation of insulin receptor signaling pathway | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of kinase activity | positive regulation of phagocytosis | regulation of cellular response to insulin stimulus | regulation of phosphate metabolic process | positive regulation of organic acid transport | cell-cell adhesion | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of MAPK cascade | positive regulation of T cell mediated immunity | temperature homeostasis | positive regulation of protein transport | regulation of reactive oxygen species biosynthetic process | negative regulation of protein metabolic process | positive regulation of fever generation | regulation of stress-activated MAPK cascade | regulation of cell communication | sequestering of triglyceride | negative regulation of molecular function | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | cell development | regulation of endocytosis | regulation of T cell proliferation | organic acid metabolic process | extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | regulation of developmental process | regulation of ion transport | developmental process | positive regulation of anion transport | positive regulation of cell cycle process | cellular protein modification process | positive regulation of prostaglandin secretion | regulation of monocyte chemotactic protein-1 production | regulation of chemokine production | positive regulation of interleukin-2 production | carbohydrate derivative metabolic process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | negative regulation of cell proliferation | regulation of cell-cell adhesion | heat generation | regulation of endothelial cell differentiation | regulation of fatty acid transport | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | regulation of defense response to virus by host | regulation of epithelial to mesenchymal transition | regulation of vascular endothelial growth factor production | positive regulation of interleukin-6 biosynthetic process | negative regulation of synaptic transmission | regulation of anion transport | positive regulation of nitric oxide biosynthetic process | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | acute inflammatory response | regulation of interferon-gamma production | positive regulation of lipid transport | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | ectopic germ cell programmed cell death | positive regulation of cell motility | response to carbohydrate | negative regulation of cell death | regulation of interleukin-6 production | neutrophil migration | regulation of inflammatory response | chemotaxis | positive regulation of endocytosis | positive regulation of leukocyte cell-cell adhesion | positive regulation of angiogenesis | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | response to other organism | positive regulation of signaling | positive regulation of mitotic nuclear division | signal transduction | regulation of signaling | regulation of p38MAPK cascade | positive regulation of fatty acid transport | positive regulation of gene expression | regulation of hormone biosynthetic process | glycosaminoglycan metabolic process | cellular response to lipopolysaccharide | macromolecule metabolic process | positive regulation of interleukin-6 secretion | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | secretory vesicle | endomembrane system | vacuole | vesicle | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | lysosome | extracellular space | cytosol | intracellular vesicle | intracellular | autophagosome
