QuickView for LDH-1;jsessionid=EA8E10623547A96152F46A2922DD6C9F;jsessionid=060E2AF03FCD1A9A0F44D97AFC402844;jsessionid=53B74746D21485F66CD934DC00C78314;jsessionid=90CF725E502FFBDB36093B3CE6C66C35 (gene)
- Gene Symbol:
- LDHA
Homo sapiens - Full name:
- lactate dehydrogenase A
- Synonyms:
- GSD11, HEL-S-133P, LDHM, PIG19, L-lactate dehydrogenase A chain, LDH muscle subunit, LDH-A, LDH-M, cell proliferation-inducing gene 19 protein, epididymis secretory sperm binding protein Li 133P, lactate dehydrogenase M, proliferation-inducing gene 19, renal carcinoma antigen NY-REN-59
- Genomic Location:
- Chr 11: 18372687-18385969
- Description:
-
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
11p15.1
GO Molecular Function
oxidoreductase activity, acting on CH-OH group of donors | kinase binding | cofactor binding | lactate dehydrogenase activity | cadherin binding | enzyme binding | nucleotide binding | coenzyme binding | catalytic activity | identical protein binding | L-lactate dehydrogenase activity | organic cyclic compound binding | cell adhesion molecule binding | protein binding | NAD binding | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
response to extracellular stimulus | purine ribonucleotide metabolic process | purine ribonucleoside monophosphate biosynthetic process | response to nutrient levels | oxidoreductase activity, acting on CH-OH group of donors | nucleoside phosphate catabolic process | positive regulation of apoptotic process | glycolytic process | regulation of programmed cell death | nicotinamide nucleotide biosynthetic process | response to drug | generation of precursor metabolites and energy | organophosphate catabolic process | lactate dehydrogenase activity | response to antibiotic | response to organophosphorus | cellular process | organic substance catabolic process | nucleotide metabolic process | ribose phosphate metabolic process | purine nucleotide biosynthetic process | response to hypoxia | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | carbohydrate catabolic process | response to inorganic substance | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | monocarboxylic acid metabolic process | response to stress | cellular nitrogen compound biosynthetic process | response to glucose | cellular nitrogen compound metabolic process | carbohydrate derivative biosynthetic process | cofactor metabolic process | cellular biosynthetic process | nucleobase-containing compound catabolic process | nucleotide biosynthetic process | organic hydroxy compound metabolic process | response to nitrogen compound | system development | ATP biosynthetic process | response to oxygen levels | nitrogen compound metabolic process | coenzyme biosynthetic process | post-embryonic animal organ development | multicellular organism development | phosphorus metabolic process | response to purine-containing compound | ribonucleoside monophosphate biosynthetic process | organophosphate metabolic process | nucleotide phosphorylation | cofactor biosynthetic process | small molecule metabolic process | response to nutrient | response to oxidative stress | nucleobase-containing small molecule metabolic process | L-lactate dehydrogenase activity | biosynthetic process | pyruvate metabolic process | aromatic compound biosynthetic process | phosphorylation | purine ribonucleotide biosynthetic process | carbohydrate metabolic process | nucleotide catabolic process | response to toxic substance | nucleoside triphosphate biosynthetic process | phosphate-containing compound metabolic process | response to estrogen | aromatic compound catabolic process | response to monosaccharide | drug metabolic process | carboxylic acid metabolic process | pyridine nucleotide biosynthetic process | response to organic substance | nucleoside diphosphate metabolic process | anatomical structure development | metabolic process | oxidation-reduction process | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | lactate metabolic process | animal organ development | response to reactive oxygen species | positive regulation of programmed cell death | ATP generation from ADP | response to cAMP | pyruvate biosynthetic process | ADP metabolic process | response to organic cyclic compound | ribose phosphate biosynthetic process | organic acid metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | developmental process | nicotinamide nucleotide metabolic process | NAD metabolic process | carbohydrate derivative metabolic process | response to organonitrogen compound | heterocycle metabolic process | cellular metabolic process | ATP metabolic process | regulation of cell death | response to carbohydrate | oxidoreductase activity | nucleoside diphosphate phosphorylation | nucleoside monophosphate biosynthetic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular | membrane
