QuickView for NEDD4;jsessionid=B516AB549947C0E8EE4A661E64F0EC3B;jsessionid=64554C3D1DED733E51A3986071A67120;jsessionid=FBBA7350AE305E1421E6D80E95EDCD66;jsessionid=5E59B1A2424366FF326346869455F2F1 (gene)
- Gene Symbol:
- Nedd4
Rattus norvegicus - Full name:
- neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
- Synonyms:
- Nedd4a, E3 ubiquitin-protein ligase NEDD4, HECT-type E3 ubiquitin transferase NEDD4, neural precursor cell expressed, developmentally down-regulated gene 4, neural precursor cell expressed, developmentally down-regulated gene 4A
- Genomic Location:
- Chr 8: 77267574-77337403
- Description:
-
may regulate function of the amiloride-sensitive epithelial sodium channel ENaC
- Orthologs:
- Homo sapiens , Mus musculus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Pan troglodytes , Bos taurus , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
protein phosphorylated amino acid binding | sodium channel inhibitor activity | beta-2 adrenergic receptor binding | RNA polymerase binding | channel regulator activity | phosphoserine residue binding | enzyme binding | sodium channel regulator activity | ion channel inhibitor activity | signaling receptor binding | ubiquitin binding | adrenergic receptor binding | molecular function regulator | catalytic activity | protein domain specific binding | channel inhibitor activity | ubiquitin-like protein transferase activity | proline-rich region binding | ubiquitin protein ligase activity | ubiquitin-like protein binding | phosphoprotein binding | protein binding | ubiquitin-protein transferase activity | G-protein coupled receptor binding | transferase activity | ubiquitin-like protein ligase activity | phosphothreonine residue binding | protein C-terminus binding | glutamate receptor binding | ionotropic glutamate receptor binding
GO Biological Process
adaptive immune response | response to radiation | regulation of muscle system process | regulation of cell morphogenesis | regulation of neurogenesis | regulation of sodium ion transmembrane transporter activity | regulation of cellular localization | proteolysis | regulation of cell development | protein localization to vacuole | regulation of localization | sodium channel inhibitor activity | regulation of sodium ion transport | establishment of localization | response to hormone | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | nervous system development | positive regulation of protein catabolic process | neurogenesis | generation of neurons | mesenchyme development | intracellular transport | hormone-mediated signaling pathway | blood vessel morphogenesis | cellular process | protein K63-linked ubiquitination | organic substance catabolic process | channel regulator activity | localization | proteolysis involved in cellular protein catabolic process | protein transport | heart morphogenesis | regulation of sodium ion transmembrane transport | negative regulation of signaling | neuron development | regulation of vascular endothelial growth factor receptor signaling pathway | regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage | negative regulation of nucleic acid-templated transcription | macromolecule localization | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | interspecies interaction between organisms | regulation of cellular process | sodium channel regulator activity | leukocyte activation | cellular response to lipid | regulation of metabolic process | catabolic process | cellular component organization | response to muscle inactivity | T cell activation | response to UV | response to stimulus | negative regulation of vascular endothelial growth factor receptor signaling pathway | lysosomal transport | vasculature development | ion channel inhibitor activity | protein targeting to lysosome | positive regulation of protein metabolic process | cellular response to light stimulus | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | intracellular protein transport | vacuolar transport | tube morphogenesis | negative regulation of transporter activity | cellular protein catabolic process | cellular localization | cardiovascular system development | proteasomal protein catabolic process | negative regulation of transport | cellular response to organic cyclic compound | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | negative regulation of metabolic process | protein modification process | steroid hormone mediated signaling pathway | regulation of synapse structure or activity | macromolecule modification | negative regulation of transmembrane transport | regulation of intracellular transport | molecular function regulator | protein targeting to vacuole | blood vessel development | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | regulation of membrane potential | locomotion | cellular response to hormone stimulus | response to light stimulus | endocardial cushion development | response to inactivity | system development | nitrogen compound metabolic process | regulation of signal transduction | protein monoubiquitination | channel inhibitor activity | negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage | multicellular organism development | response to denervation involved in regulation of muscle adaptation | cellular response to DNA damage stimulus | protein localization to lysosome | negative regulation of sodium ion transmembrane transporter activity | regulation of neuron differentiation | regulation of gene expression | outflow tract morphogenesis | organic substance transport | cellular response to stress | response to lipid | protein catabolic process | neuromuscular junction development | progesterone receptor signaling pathway | cellular response to radiation | animal organ morphogenesis | regulation of synapse organization | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | peptide transport | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of transcription by RNA polymerase II | ubiquitin protein ligase activity | synapse organization | protein localization to organelle | glucocorticoid receptor signaling pathway | negative regulation of ion transmembrane transport | negative regulation of ion transport | cellular response to UV | regulation of potassium ion transmembrane transporter activity | cell communication | regulation of cellular metabolic process | receptor internalization | regulation of protein metabolic process | positive regulation of signal transduction | heart development | regulation of RNA metabolic process | positive regulation of transport | viral process | regulation of cellular response to growth factor stimulus | proteasome-mediated ubiquitin-dependent protein catabolic process | lymphocyte activation | regulation of potassium ion transport | regulation of nucleocytoplasmic transport | protein polyubiquitination | neuron differentiation | regulation of cell morphogenesis involved in differentiation | protein metabolic process | response to organic substance | receptor catabolic process | protein ubiquitination | import into cell | regulation of intracellular signal transduction | cellular macromolecule catabolic process | establishment of protein localization to organelle | anatomical structure development | regulation of dendrite morphogenesis | cell projection organization | metabolic process | regulation of DNA-templated transcription in response to stress | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | amide transport | endocytosis | immune response | neuron projection development | negative regulation of ion transmembrane transporter activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of sodium ion transmembrane transport | protein modification by small protein conjugation or removal | establishment of protein localization to vacuole | cellular response to steroid hormone stimulus | regulation of ion transmembrane transport | establishment of protein localization | positive regulation of intracellular transport | cell activation | intracellular receptor signaling pathway | transmission of virus | ubiquitin-dependent protein catabolic process | regulation of dendrite development | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cell development | regulation of transmembrane transporter activity | protein localization | regulation of ion transmembrane transporter activity | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | anatomical structure morphogenesis | cellular macromolecule localization | regulation of nervous system development | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | developmental process | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | receptor metabolic process | positive regulation of metabolic process | protein targeting | negative regulation of sodium ion transport | regulation of cell projection organization | immune system process | cellular metabolic process | cellular response to organic substance | response to steroid hormone | modification-dependent protein catabolic process | circulatory system development | positive regulation of nucleocytoplasmic transport | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | macromolecule metabolic process | development involved in symbiotic interaction | multicellular organismal process
GO Cellular Component
dendritic spine | chromosome | dendrite | intracellular membrane-bounded organelle | synapse | catalytic complex | neuron projection | somatodendritic compartment | actin-based cell projection | cell | cytoplasm | intracellular organelle | membrane microdomain | ubiquitin ligase complex | dendritic tree | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | neuron spine | postsynapse | plasma membrane | chromatin | membrane raft | transferase complex | perinuclear region of cytoplasm | cytoplasmic region | cell cortex | microvillus | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular | membrane
