QuickView for NLRA;jsessionid=B8FB9907F617B83DC72E0486987C202A;jsessionid=FC47020FE99AFA898DC7F5B15C8F9688 (gene)
- Gene Symbol:
- Ciita
Mus musculus - Full name:
- class II transactivator
- Synonyms:
- C2ta, EG669998, Gm9475, Mhc2ta, MHC class II transactivator
- Genomic Location:
- Chr 16: 10488372-10527657
- Description:
-
This gene encodes a member of the NOD-like receptor protein family. This protein acts as a transcriptional coactivator and component of the enhanceosome complex to stimulate transcription of MHC class II genes in the adaptive immune response. This protein may also regulate the transcription of MHC class I genes. Mutations in the human gene have bee...
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
guanyl ribonucleotide binding | transcription regulatory region DNA binding | ribonucleoside binding | nucleic acid binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | transferase activity, transferring acyl groups | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine nucleoside binding | purine ribonucleoside triphosphate binding | protein binding | transcription factor binding | activating transcription factor binding | transferase activity, transferring phosphorus-containing groups | GTP binding | transferase activity | nucleoside binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | protein C-terminus binding | guanyl nucleotide binding | small molecule binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | response to cytokine | negative regulation of cellular process | negative regulation of RNA biosynthetic process | defense response | response to antibiotic | positive regulation of cellular biosynthetic process | cellular process | regulation of MHC class I biosynthetic process | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | phosphorus metabolic process | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | phosphorylation | phosphate-containing compound metabolic process | regulation of cellular metabolic process | regulation of RNA metabolic process | positive regulation of MHC class II biosynthetic process | response to organic substance | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | transcription, DNA-templated | response to interferon-gamma | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | kinase activity | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | positive regulation of MHC class I biosynthetic process | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nuclear body | PML body | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cell surface | intracellular
