QuickView for OCLN;jsessionid=CB04978FB0DC8B5BD46DEB87AC215E6B;jsessionid=49E9A6E5743CAEB3C3336FAF332C74EC;jsessionid=FFA11E9A7280805AE56B13E3D43BE9B7;jsessionid=E9E9C1649595FB26309978508443182F (gene)

Gene Symbol:

OCLN Homo sapiens

Full name:

occludin

Synonyms:

BLCPMG, PPP1R115, PTORCH1, occludin, phosphatase 1, regulatory subunit 115, tight junction protein occludin

Genomic Location:

N/A

Description:

This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as p...

View Full Description

This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  FXR_Q3 ,  ACACTCC_MIR122A ,  AREB6_02 ,  GGGAGGRR_MAZ_Q6 ,  GGATTA_PITX2_Q2 ,  CAGGTG_E12_Q6 ,  TAATTA_CHX10_01 ,  CAGTATT_MIR200B_MIR200C_MIR429

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-122a ,  Predicted Gene Targets for miR-200b

search → result