QuickView for PLK1;jsessionid=79F262793D6031E626261D39DE822608;jsessionid=65A1B6D3E4FA69B6EE44624606C26537 (gene)
- Gene Symbol:
- PLK1
Bos taurus - Full name:
- polo-like kinase 1 (Drosophila)
- Synonyms:
- MGC133927
- Genomic Location:
- Chr 25: 22513534-22524076
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
kinase binding | cation binding | protein kinase binding | magnesium ion binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | anaphase-promoting complex binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | microtubule binding | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
mitotic cytokinesis | negative regulation of phosphorylation | nucleus organization | regulation of cell cycle process | intracellular signal transduction | microtubule bundle formation | regulation of programmed cell death | peptidyl-amino acid modification | positive regulation of peptidyl-threonine phosphorylation | establishment of localization | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | regulation of organelle organization | membrane organization | microtubule-based process | regulation of chromosome segregation | cellular process | localization | regulation of ubiquitin-protein transferase activity | cytoskeleton-dependent cytokinesis | regulation of mitotic nuclear division | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of chromosome separation | macromolecule localization | negative regulation of chromosome segregation | negative regulation of apoptotic process | endomembrane system organization | microtubule organizing center organization | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | membrane disassembly | positive regulation of nitrogen compound metabolic process | regulation of mitotic spindle organization | negative regulation of cellular metabolic process | regulation of binding | gamete generation | negative regulation of mitotic metaphase/anaphase transition | spindle checkpoint | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of ubiquitin protein ligase activity | positive regulation of cellular protein metabolic process | cellular component organization | regulation of cell division | positive regulation of cellular protein catabolic process | response to stimulus | female gamete generation | female meiosis chromosome segregation | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | negative regulation of protein kinase activity | regulation of protein ubiquitination | synaptonemal complex disassembly | protein localization to nucleus | regulation of cell cycle phase transition | protein serine/threonine kinase activity | protein destabilization | positive regulation of proteolysis involved in cellular protein catabolic process | reproduction | cellular localization | positive regulation of proteolysis | nuclear envelope organization | negative regulation of metabolic process | protein modification process | macromolecule modification | regulation of mitotic spindle assembly | meiotic chromosome segregation | regulation of nucleic acid-templated transcription | regulation of cell cycle G2/M phase transition | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | regulation of protein stability | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | negative regulation of cyclin-dependent protein serine/threonine kinase activity | regulation of spindle assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of protein serine/threonine kinase activity | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of mitotic nuclear division | cell division | regulation of cellular protein metabolic process | synaptonemal complex organization | positive regulation of proteasomal protein catabolic process | G2/M transition of mitotic cell cycle | cytokinesis | phosphorylation | signal transduction involved in cell cycle checkpoint | mitotic spindle assembly checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | nuclear chromosome segregation | protein localization to chromatin | nuclear envelope disassembly | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of mitotic sister chromatid segregation | regulation of cytokinesis | regulation of protein metabolic process | cell cycle G2/M phase transition | negative regulation of mitotic sister chromatid separation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of mitotic cell cycle | regulation of microtubule-based process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | multicellular organism reproduction | negative regulation of cyclin-dependent protein kinase activity | homologous chromosome segregation | protein metabolic process | positive regulation of protein modification process | protein ubiquitination | centrosome cycle | protein localization to nuclear envelope | regulation of kinase activity | regulation of sister chromatid segregation | mitotic cell cycle | nuclear division | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of mitotic cell cycle | cellular protein localization | signal transduction involved in G2 DNA damage checkpoint | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | cytoskeleton organization | regulation of chromosome organization | mitotic nuclear division | establishment of protein localization | meiosis I | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of mitotic sister chromatid segregation | meiotic cell cycle | negative regulation of chromosome organization | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | regulation of protein binding | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | cellular macromolecule localization | signal transduction involved in DNA damage checkpoint | kinase activity | organelle organization | peptidyl-serine phosphorylation | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of mitotic metaphase/anaphase transition | cell cycle phase transition | positive regulation of ubiquitin-protein transferase activity | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | regulation of organelle assembly | DNA damage checkpoint | cell cycle checkpoint | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | mitotic sister chromatid segregation | sexual reproduction | positive regulation of protein ubiquitination | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | protein localization to chromosome | signal transduction | female meiotic nuclear division | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
condensed nuclear chromosome | supramolecular fiber | chromosome | centriole | intracellular membrane-bounded organelle | condensed nuclear chromosome kinetochore | microtubule organizing center | chromosome, centromeric region | condensed chromosome outer kinetochore | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | synaptonemal complex | microtubule | cytoplasm | spindle | centriolar satellite | intracellular organelle | centrosome | protein-containing complex | midbody | chromatin | condensed nuclear chromosome, centromeric region | nuclear chromosome | condensed chromosome kinetochore | microtubule cytoskeleton | spindle pole | spindle microtubule | spindle midzone | membrane-bounded organelle | condensed nuclear chromosome outer kinetochore | nucleus | organelle | membrane-enclosed lumen | cytoskeleton | intracellular | supramolecular complex | condensed chromosome
