QuickView for SERPINE1;jsessionid=E99CE55BEE13BF8EBACC9AA6FECC23F5;jsessionid=52AD71536039B966FEBBF666F510F71D;jsessionid=12ED602ADC86FDE538364295A17D268E;jsessionid=FF3CCDD358639E92103F642C2B14064E (gene)
- Gene Symbol:
- Serpine1
Rattus norvegicus - Full name:
- serpin family E member 1
- Synonyms:
- PAI1A, Pai1, Pai1aa, Planh, RATPAI1A, plasminogen activator inhibitor 1, PAI, PAI-1, endothelial plasminogen activator inhibitor, serine (or cysteine) peptidase inhibitor, clade E, member 1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1, serine (or cysteine) proteinase inhibitor, clade E, member 1, serine (or cysteine) proteinase inhibitor, member 1, serpin E1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
- Genomic Location:
- Chr 12: 20931996-20942374
- Description:
-
mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator; may promote neuronal survival
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Danio rerio , Bos taurus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
endopeptidase inhibitor activity | enzyme binding | enzyme inhibitor activity | signaling receptor binding | molecular function regulator | protein binding | serine-type endopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding
GO Biological Process
response to extracellular stimulus | regulation of leukocyte chemotaxis | regulation of odontoblast differentiation | cellular response to decreased oxygen levels | positive regulation of locomotion | response to nutrient levels | endopeptidase inhibitor activity | response to ATP | response to cytokine | response to interleukin-1 | cellular response to glucose stimulus | positive regulation of cellular component organization | cellular response to cycloheximide | response to lipopolysaccharide | response to cGMP | developmental process involved in reproduction | cellular response to platelet-derived growth factor stimulus | cellular response to aldosterone | regulation of localization | positive regulation of collagen metabolic process | gonad development | regulation of programmed cell death | female gonad development | response to cycloheximide | defense response to other organism | regulation of immune system process | response to hormone | negative regulation of cellular process | positive regulation of developmental process | response to potassium ion | response to dexamethasone | response to metal ion | positive regulation of fibroblast proliferation | maternal placenta development | defense response | negative regulation of cell-matrix adhesion | cellular response to extracellular stimulus | response to drug | cellular chemical homeostasis | glucose homeostasis | positive regulation of cellular component movement | response to antibiotic | defense response to Gram-negative bacterium | negative regulation of proteolysis | blood vessel morphogenesis | response to organophosphorus | cellular process | positive regulation of keratinocyte migration | regulation of cell motility | cellular homeostasis | odontogenesis | negative regulation of smooth muscle cell migration | negative regulation of signaling | developmental growth | positive regulation of blood coagulation | reproductive system development | female pregnancy | multicellular organismal reproductive process | cellular response to potassium ion | regulation of chemotaxis | negative regulation of apoptotic process | response to hypoxia | negative regulation of smooth muscle cell-matrix adhesion | regulation of proteolysis | regulation of monocyte chemotaxis | response to growth factor | negative regulation of cell migration | response to inorganic substance | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | mast cell activation | regulation of cell differentiation | cellular response to low-density lipoprotein particle stimulus | negative regulation of apoptotic signaling pathway | negative regulation of vascular wound healing | regeneration | response to hydrogen peroxide | negative regulation of cell motility | negative regulation of wound healing | regulation of angiogenesis | positive regulation of interleukin-8 production | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | response to nerve growth factor | cellular response to organonitrogen compound | response to gravity | response to transforming growth factor beta | cellular response to metal ion | positive regulation of epithelial cell migration | development of primary sexual characteristics | response to stilbenoid | regulation of vasculature development | response to stimulus | enzyme inhibitor activity | negative regulation of epithelial cell apoptotic process | vasculature development | cellular response to mechanical stimulus | cellular response to fibroblast growth factor stimulus | positive regulation of immune system process | regulation of plasminogen activation | negative regulation of cell adhesion | cellular response to xenobiotic stimulus | cellular response to hypoxia | response to stress | regulation of cell proliferation | negative regulation of angiogenesis | response to laminar fluid shear stress | tube morphogenesis | response to peptide | response to glucose | response to starvation | regulation of epithelial cell differentiation | regulation of smooth muscle cell migration | development of primary female sexual characteristics | reproduction | cellular response to inorganic substance | response to alcohol | cardiovascular system development | response to molecule of bacterial origin | cellular response to toxic substance | cellular response to organic cyclic compound | negative regulation of metabolic process | regulation of wound healing | regulation of protein processing | regulation of cell adhesion | molecular function regulator | blood vessel development | response to nitrogen compound | cellular response to hormone stimulus | response to nicotine | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | positive regulation of response to wounding | reproductive process | regulation of signal transduction | positive regulation of monocyte chemotaxis | cellular response to antibiotic | multicellular organism development | negative regulation of catalytic activity | cellular glucose homeostasis | cellular response to peptide hormone stimulus | regulation of peptidase activity | response to purine-containing compound | regulation of collagen biosynthetic process | positive regulation of inflammatory response | response to follicle-stimulating hormone | cellular response to insulin stimulus | regulation of catalytic activity | cellular response to oxidative stress | cellular response to nerve growth factor stimulus | negative regulation of peptidase activity | wound healing | positive regulation of calcium ion import | regulation of receptor-mediated endocytosis | positive regulation of receptor-mediated endocytosis | regulation of gene expression | positive regulation of chemotaxis | regulation of extrinsic apoptotic signaling pathway | positive regulation of leukotriene production involved in inflammatory response | cellular response to ATP | response to ketone | cellular response to stress | response to lipid | cellular response to peptide | cellular response to gonadotropin stimulus | animal organ morphogenesis | regulation of blood coagulation | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | response to corticosteroid | regulation of cellular component movement | response to nutrient | regulation of endothelial cell apoptotic process | response to oxidative stress | dentinogenesis | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | response to platelet-derived growth factor | positive regulation of cell migration | cellular response to cytokine stimulus | regulation of cellular protein metabolic process | negative regulation of cell-substrate adhesion | angiogenesis | cellular response to glucocorticoid stimulus | regulation of cell adhesion mediated by integrin | response to hyperoxia | response to toxic substance | regulation of apoptotic signaling pathway | response to xenobiotic stimulus | regulation of smooth muscle cell-matrix adhesion | regulation of epithelial cell apoptotic process | cellular response to corticosteroid stimulus | regulation of leukocyte migration | cellular response to angiotensin | cellular response to drug | negative regulation of response to wounding | response to bacterium | response to estrogen | cell communication | regulation of cellular metabolic process | positive regulation of leukocyte chemotaxis | odontogenesis of dentin-containing tooth | negative regulation of protein processing | regulation of collagen metabolic process | regulation of protein metabolic process | response to aldosterone | chronological cell aging | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | regulation of locomotion | positive regulation of transport | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | cell aging | cellular response to lipoprotein particle stimulus | decidualization | cellular response to nicotine | negative regulation of plasminogen activation | cellular response to mineralocorticoid stimulus | cellular response to transforming growth factor beta stimulus | response to angiotensin | multicellular organism reproduction | regulation of signaling receptor activity | maternal process involved in female pregnancy | response to glucagon | cellular response to nutrient | regulation of fibroblast proliferation | response to organic substance | response to wounding | response to antineoplastic agent | positive regulation of odontoblast differentiation | response to mechanical stimulus | replicative senescence | positive regulation of mononuclear cell migration | response to insulin | anatomical structure development | response to mineralocorticoid | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of coagulation | cellular response to carbohydrate stimulus | cellular response to hydrogen peroxide | regulation of vesicle-mediated transport | chemical homeostasis | cellular response to cGMP | cellular response to reactive oxygen species | negative regulation of gene expression | animal organ development | positive regulation of ion transport | response to reactive oxygen species | response to resveratrol | negative regulation of cellular protein metabolic process | negative regulation of cellular component movement | positive regulation of leukocyte migration | cellular response to resveratrol | cellular response to cAMP | positive regulation of wound healing | cellular response to steroid hormone stimulus | positive regulation of cytokine production | serine-type endopeptidase inhibitor activity | response to gonadotropin | response to cAMP | cell activation | cellular response to follicle-stimulating hormone stimulus | cellular response to dexamethasone stimulus | response to epidermal growth factor | anatomical structure formation involved in morphogenesis | negative regulation of protein metabolic process | regulation of epithelial cell migration | cellular response to gravity | response to fungicide | regulation of calcium ion import | response to fluid shear stress | regulation of response to wounding | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | cellular response to leukemia inhibitory factor | response to organic cyclic compound | regulation of endocytosis | regulation of fibrinolysis | peptidase inhibitor activity | enzyme regulator activity | regulation of cytokine production | anatomical structure morphogenesis | regulation of endopeptidase activity | response to biotic stimulus | reproductive structure development | regulation of developmental process | regulation of ion transport | developmental process | cellular response to interleukin-1 | regulation of calcium ion transport | positive regulation of epithelial cell differentiation | tube development | regulation of transport | negative regulation of cell adhesion mediated by integrin | negative regulation of vasculature development | response to fibroblast growth factor | response to organonitrogen compound | regulation of vascular wound healing | negative regulation of hydrolase activity | positive regulation of metabolic process | immune system process | positive regulation of collagen biosynthetic process | placenta development | negative regulation of fibrinolysis | female sex differentiation | cellular response to organic substance | regulation of cell death | sex differentiation | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | negative regulation of cell death | circulatory system development | regulation of inflammatory response | aging | carbohydrate homeostasis | cellular response to glucagon stimulus | negative regulation of locomotion | tissue regeneration | positive regulation of endocytosis | positive regulation of angiogenesis | regulation of cellular component organization | positive regulation of calcium ion transport | response to other organism | regulation of signaling | negative regulation of endopeptidase activity | negative regulation of endothelial cell apoptotic process | positive regulation of gene expression | response to glucocorticoid | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | multicellular organismal process
GO Cellular Component
secretory granule | chromaffin granule | extracellular matrix | cytoplasmic vesicle | cell | cytoplasm | collagen-containing extracellular matrix | intracellular organelle | secretory vesicle | endomembrane system | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | intracellular vesicle | intracellular
