QuickView for SGK-1;jsessionid=F53A3B3E54E9317A220D539A68200A67;jsessionid=7A563A8EB63D1C59C94A796863E2770A (gene)

Gene Symbol:

Sgk1 Mus musculus

Full name:

serum/glucocorticoid regulated kinase 1

Synonyms:

Sgk, serine/threonine-protein kinase Sgk1, serum and glucocorticoid-dependent protein kinase

Genomic Location:

Chr 10: 21714502-21719698

Description:

This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein p...

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This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATF_01 ,  FOXD3_01 ,  AHRARNT_01 ,  OLF1_01 ,  HFH3_01 ,  FAC1_01 ,  AR_01 ,  BACH2_01 ,  STAT6_01 ,  BACH1_01 ,  STAT4_01 ,  STAT6_02 ,  ATF4_Q2 ,  HTF_01 ,  ARNT_02 ,  LXR_Q3 ,  HNF3ALPHA_Q6 ,  OSF2_Q6 ,  HFH4_01 ,  IRF1_Q6 ,  HNF4_DR1_Q3 ,  LXR_DR4_Q3 ,  HNF3_Q6 ,  USF_Q6_01 ,  SRF_Q4 ,  SRF_Q5_01 ,  AP1_Q6_01 ,  DR4_Q2 ,  DR3_Q4 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  AATGTGA_MIR23A_MIR23B ,  TTTGCAC_MIR19A_MIR19B ,  GTGCCTT_MIR506 ,  ACAACTT_MIR382 ,  GTTTGTT_MIR495 ,  GGGCATT_MIR365 ,  GTAAGAT_MIR200A ,  ATGTCAC_MIR489 ,  ACACTAC_MIR1423P ,  GTAAACC_MIR2995P ,  TGANTCA_AP1_C ,  RYTTCCTG_ETS2_B ,  TTGTTT_FOXO4_01 ,  AAAYWAACM_HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  CACGTG_MYC_Q2 ,  TGGAAA_NFAT_Q4_01 ,  GGGCGGR_SP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-382 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-495

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