QuickView for SIRT3;jsessionid=8D29E90D40486E6ED67ECF0D0F82FCAD (gene)
- Gene Symbol:
- Sirt3
Mus musculus - Full name:
- sirtuin 3
- Synonyms:
- 2310003L23Rik, AI848213, Sir2l3, NAD-dependent protein deacetylase sirtuin-3, NAD-dependent deacetylase sirtuin-3, SIR2-like protein 3, SIRT3L mitochondrial, mSIR2L3, mitochondrial protein lysine deacetylase, regulatory protein SIR2 homolog 3, silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
- Genomic Location:
- Chr 7: 148049569-148068208
- Orthologs:
- Homo sapiens , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | cofactor binding | cation binding | histone deacetylase activity (H3-K14 specific) | enzyme binding | nucleic acid binding | nucleotide binding | coenzyme binding | NAD-dependent histone deacetylase activity (H3-K14 specific) | hydrolase activity | protein deacetylase activity | NAD+ binding | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | histone deacetylase activity | DNA binding | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | protein binding | zinc ion binding | NAD binding | transition metal ion binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | positive regulation of macromolecule biosynthetic process | negative regulation of MAPK cascade | regulation of localization | peptidyl-amino acid modification | negative regulation of cellular process | histone modification | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | histone deacetylation | aerobic respiration | regulation of peptide hormone secretion | positive regulation of protein secretion | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | negative regulation of signaling | cellular respiration | positive regulation of nitrogen compound metabolic process | histone deacetylase activity (H3-K14 specific) | negative regulation of peptidyl-lysine acetylation | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | cellular component organization | regulation of peptide secretion | regulation of insulin secretion | NAD-dependent histone deacetylase activity (H3-K14 specific) | positive regulation of hormone secretion | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | regulation of peptide transport | macromolecule modification | negative regulation of ERK1 and ERK2 cascade | histone H3 deacetylation | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | NAD-dependent protein deacetylase activity | regulation of MAPK cascade | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | regulation of gene expression | histone deacetylase activity | positive regulation of secretion | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein deacetylation | regulation of cellular protein metabolic process | NAD-dependent histone deacetylase activity | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | positive regulation of peptide hormone secretion | protein metabolic process | regulation of establishment of protein localization | positive regulation of insulin secretion | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | metabolic process | regulation of RNA biosynthetic process | oxidation-reduction process | peptidyl-lysine modification | regulation of secretion | organic substance metabolic process | negative regulation of cellular protein metabolic process | regulation of protein secretion | regulation of phosphate metabolic process | positive regulation of protein transport | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | positive regulation of mitochondrial transcription | energy derivation by oxidation of organic compounds | organelle organization | peptidyl-lysine deacetylation | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of protein localization | regulation of mitochondrial transcription | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | cytoplasm | intracellular organelle | protein-containing complex | mitochondrion | membrane-bounded organelle | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
