QuickView for SREBP-1C;jsessionid=96F08608B5678E4B99BE885C2C219EE4;jsessionid=7F3BD71821DA2ED729C5829FA730B2B4 (gene)
- Gene Symbol:
- Srebf1
Mus musculus - Full name:
- sterol regulatory element binding transcription factor 1
- Synonyms:
- ADD1, SREBP1, bHLHd1, sterol regulatory element-binding protein 1, adipocyte determination- and differentiation-dependent factor 1
- Genomic Location:
- Chr 11: 60012591-60034106
- Description:
-
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mat...
- Orthologs:
- Homo sapiens , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
sequence-specific DNA binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nuclear receptor activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | protein-containing complex binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | sterol response element binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | positive regulation of cellular component organization | regulation of cellular localization | negative regulation of peptide secretion | regulation of localization | regulation of autophagy | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | cellular response to extracellular stimulus | negative regulation of protein secretion | regulation of organelle organization | regulation of peptide hormone secretion | sterol metabolic process | positive regulation of cellular biosynthetic process | cellular process | nuclear receptor activity | negative regulation of signaling | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of secretion | cellular response to starvation | positive regulation of nitrogen compound metabolic process | negative regulation of hormone secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | response to peptide hormone | positive regulation of triglyceride biosynthetic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | positive regulation of cholesterol biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of cellular protein localization | regulation of fatty acid biosynthetic process | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | cellular nitrogen compound biosynthetic process | alcohol metabolic process | positive regulation of lipid biosynthetic process | regulation of heart rate by chemical signal | regulation of blood circulation | response to peptide | circadian rhythm | response to glucose | response to starvation | positive regulation of protein deacetylation | regulation of heart rate | rhythmic process | cellular nitrogen compound metabolic process | negative regulation of transport | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | mRNA metabolic process | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | regulation of triglyceride metabolic process | regulation of steroid metabolic process | regulation of intracellular transport | regulation of nucleic acid-templated transcription | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | cellular response to nutrient levels | nitrogen compound metabolic process | positive regulation of organelle organization | negative regulation of secretion by cell | regulation of protein stability | cellular response to peptide hormone stimulus | cellular response to insulin stimulus | lipid metabolic process | regulation of hormone levels | regulation of hormone secretion | mRNA transcription by RNA polymerase II | regulation of cholesterol biosynthetic process | positive regulation of chromosome organization | regulation of gene expression | cellular response to stress | cellular response to peptide | insulin receptor signaling pathway | positive regulation of cellular metabolic process | regulation of pri-miRNA transcription by RNA polymerase II | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | small molecule metabolic process | regulation of transcription by RNA polymerase II | fat cell differentiation | regulation of fatty acid metabolic process | regulation of cholesterol metabolic process | positive regulation of steroid metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of peptide hormone secretion | positive regulation of pri-miRNA transcription by RNA polymerase II | lipid biosynthetic process | positive regulation of fatty acid biosynthetic process | regulation of heart contraction | regulation of mitochondrion organization | positive regulation of histone deacetylation | cell communication | regulation of cellular metabolic process | regulation of protein deacetylation | regulation of protein metabolic process | mRNA transcription | response to monosaccharide | regulation of RNA metabolic process | regulation of lipid biosynthetic process | regulation of autophagy of mitochondrion | positive regulation of triglyceride metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | positive regulation of steroid biosynthetic process | positive regulation of fatty acid metabolic process | response to insulin | cell surface receptor signaling pathway | metabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | cholesterol metabolic process | negative regulation of transcription, DNA-templated | regulation of secretion | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | gene expression | regulation of protein secretion | regulation of chromosome organization | positive regulation of cholesterol metabolic process | transcription, DNA-templated | intracellular receptor signaling pathway | steroid metabolic process | regulation of cell communication | negative regulation of insulin secretion | signaling | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | regulation of cellular ketone metabolic process | developmental process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of histone deacetylation | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | response to carbohydrate | regulation of triglyceride biosynthetic process | regulation of cellular component organization | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | regulation of protein targeting to mitochondrion | regulation of chromatin organization
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | protein-containing complex | endomembrane system | vesicle | membrane-bounded organelle | nucleus | organelle | intracellular vesicle | intracellular | membrane
