QuickView for SRs;jsessionid=A0024AE4B2E50F08BC8CB3580A67223A;jsessionid=ED4D5A0C6E888950A1BCC320484AD049;jsessionid=AF012A667E23B5D190D0A18AF2E9A779 (gene)

Gene Symbol:

SARS2 Homo sapiens

Full name:

seryl-tRNA synthetase 2, mitochondrial

Synonyms:

SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS, serine--tRNA ligase, mitochondrial, mitochondrial seryl-tRNA synthetase, serine tRNA ligase 2, mitochondrial, seryl-tRNA synthetase, mitochondrial, seryl-tRNA(Ser/Sec) synthetase

Genomic Location:

Chr 19: 44097746-44113376

Description:

This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. I...

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This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  POU1F1_Q6

Cytogenetic Map:

19q13.2

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