QuickView for Slmb;jsessionid=22007B9034255387C1BB67336BA423F2;jsessionid=5A891C1F21F915D4F6FFF087F50913E4 (gene)

Gene Symbol:

BTRC Homo sapiens

Full name:

beta-transducin repeat containing E3 ubiquitin protein ligase

Synonyms:

BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP, F-box/WD repeat-containing protein 1A, E3RSIkappaB, F-box and WD repeats protein beta-TrCP, F-box and WD-repeat protein 1B, beta-TrCP1, epididymis tissue protein Li 2a, pIkappaBalpha-E3 receptor subunit

Genomic Location:

Chr 10: 103103815-103307060

Description:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into ...

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_03 ,  EFC_Q6 ,  GATA_C ,  ZF5_01 ,  GATAAGR_GATA_C ,  GGTGAAG_MIR412 ,  GCCATNTTG_YY1_Q6 ,  RFX1_01 ,  WHN_B ,  YY1_Q6 ,  ATGCTGC_MIR103_MIR107 ,  AACYNNNNTTCCS_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  TGCTTTG_MIR330 ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  ACAGGGT_MIR10A_MIR10B ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ACACTGG_MIR199A_MIR199B ,  STAT5A_02

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-503 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

10q24.32

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