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QuickView for TCF-1;jsessionid=0BF9E9325C8DAC20E31ACF2C60F82F41;jsessionid=B34DBF8F09779EE3AB62A7A377E42891 (gene)


Gene Symbol:
Tcf7l2 Rattus norvegicus Rattus norvegicus
Full name:
transcription factor 7 like 2
Synonyms:
transcription factor 7-like 2, transcription factor 7-like 2 (T-cell specific, HMG-box)
Genomic Location:
Chr 1: 262031772-262226710
Orthologs:
Homo sapiens Mus musculus D. melanogaster Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):





GO Molecular Function

sequence-specific DNA binding | beta-catenin binding | kinase binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | repressing transcription factor binding | hormone receptor binding | protein kinase binding | proximal promoter sequence-specific DNA binding | enzyme binding | nucleic acid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | protein domain specific binding | RNA polymerase II repressing transcription factor binding | RNA polymerase II regulatory region DNA binding | gamma-catenin binding | armadillo repeat domain binding | DNA binding | sequence-specific double-stranded DNA binding | nuclear hormone receptor binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | brain development | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | response to nutrient levels | embryonic genitalia morphogenesis | regulation of neurogenesis | developmental process involved in reproduction | regulation of cellular localization | positive regulation of apoptotic process | regulation of cell development | regulation of localization | somatic stem cell population maintenance | regulation of carbohydrate metabolic process | regulation of programmed cell death | negative regulation of BMP signaling pathway | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | glucose metabolic process | cell differentiation | positive regulation of epithelial cell proliferation | bone mineralization | hindgut development | negative regulation of fat cell differentiation | negative regulation of organ growth | nervous system development | cellular response to extracellular stimulus | multicellular organism growth | generation of precursor metabolites and energy | cellular chemical homeostasis | regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter | neurogenesis | glucose homeostasis | regulation of peptide hormone secretion | generation of neurons | positive regulation of protein secretion | positive regulation of cellular biosynthetic process | cellular process | positive regulation of glycoprotein biosynthetic process | localization | cellular homeostasis | odontogenesis | negative regulation of signaling | developmental growth | positive regulation of protein export from nucleus | negative regulation of developmental growth | reproductive system development | canonical Wnt signaling pathway | positive regulation of epithelial to mesenchymal transition | hindgut morphogenesis | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | regulation of striated muscle tissue development | digestive tract morphogenesis | cellular response to starvation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | diencephalon development | regulation of canonical Wnt signaling pathway | regulation of protein export from nucleus | negative regulation of cellular metabolic process | tissue development | positive regulation of triglyceride biosynthetic process | regulation of binding | regulation of fat cell differentiation | regulation of cell differentiation | muscle structure development | regulation of protein kinase B signaling | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | head morphogenesis | gliogenesis | pituitary gland development | organelle localization | negative regulation of fibroblast growth factor receptor signaling pathway | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | positive regulation of protein binding | head development | regulation of peptide secretion | response to stimulus | positive regulation of heparan sulfate proteoglycan biosynthetic process | vasculature development | regulation of glycoprotein biosynthetic process | regulation of cellular protein localization | oligodendrocyte development | regulation of insulin secretion | positive regulation of protein metabolic process | response to stress | cellular polysaccharide metabolic process | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of lipid biosynthetic process | tube morphogenesis | polysaccharide metabolic process | response to glucose | response to starvation | reproduction | cellular localization | cardiovascular system development | embryonic digestive tract morphogenesis | cellular nitrogen compound metabolic process | positive regulation of hormone secretion | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | regulation of peptide transport | cellular biosynthetic process | embryo development | regulation of triglyceride metabolic process | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | regulation of oligodendrocyte differentiation | regulation of intracellular transport | cell surface receptor signaling pathway involved in cell-cell signaling | blood vessel development | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of skeletal muscle tissue development | system development | cellular response to nutrient levels | glycogen metabolic process | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | Wnt signaling pathway | negative regulation of growth | multicellular organism development | cellular glucose homeostasis | regulation of BMP signaling pathway | positive regulation of protein kinase B signaling | regulation of insulin secretion involved in cellular response to glucose stimulus | positive regulation of gluconeogenesis | regulation of hormone levels | regulation of hormone secretion | embryonic digestive tract development | regulation of gene expression | myoblast fate commitment | positive regulation of secretion | cellular response to stress | cell cycle | positive regulation of intracellular protein transport | regulation of fibroblast growth factor receptor signaling pathway | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of myelination | regulation of nitrogen compound metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | negative regulation of cellular response to growth factor stimulus | negative regulation of DNA-binding transcription factor activity | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | fat cell differentiation | positive regulation of cell differentiation | cell proliferation | biosynthetic process | neural tube development | regulation of hormone metabolic process | aromatic compound biosynthetic process | glial cell differentiation | digestive tract development | carbohydrate metabolic process | skin development | maintenance of DNA repeat elements | endocrine system development | post-embryonic development | chordate embryonic development | cell communication | regulation of cellular metabolic process | odontogenesis of dentin-containing tooth | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | response to monosaccharide | positive regulation of establishment of protein localization | embryonic hindgut morphogenesis | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | positive regulation of transport | genitalia development | positive regulation of peptide hormone secretion | regulation of lipid biosynthetic process | regulation of cellular response to growth factor stimulus | canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition | embryonic morphogenesis | positive regulation of molecular function | regulation of nucleocytoplasmic transport | embryonic organ morphogenesis | positive regulation of triglyceride metabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | regulation of growth | response to organic substance | gland development | positive regulation of insulin secretion | digestive system development | cell cycle arrest | DNA metabolic process | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | face morphogenesis | anatomical structure development | cell surface receptor signaling pathway | regulation of glucose metabolic process | metabolic process | cell fate commitment | positive regulation of glucose metabolic process | regulation of RNA biosynthetic process | hexose metabolic process | oxidation-reduction process | negative regulation of transcription, DNA-templated | embryonic organ development | oligodendrocyte differentiation | chemical homeostasis | regulation of secretion | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | gene expression | positive regulation of proteoglycan biosynthetic process | regulation of protein secretion | positive regulation of programmed cell death | regulation of Wnt signaling pathway | genitalia morphogenesis | insulin metabolic process | biomineral tissue development | positive regulation of binding | positive regulation of glycoprotein metabolic process | transcription, DNA-templated | positive regulation of intracellular transport | positive regulation of protein transport | negative regulation of cell cycle | positive regulation of carbohydrate metabolic process | secretory granule localization | regulation of glial cell differentiation | regulation of cell communication | regulation of gliogenesis | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of protein binding | glial cell development | myoblast differentiation | cell development | energy reserve metabolic process | regulation of developmental growth | regulation of epithelial cell proliferation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of organ growth | reproductive structure development | regulation of nervous system development | regulation of developmental process | energy derivation by oxidation of organic compounds | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | cellular glucan metabolic process | negative regulation of transcription by RNA polymerase II | tube development | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of epithelial to mesenchymal transition | heterocycle metabolic process | regulation of gluconeogenesis | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | negative regulation of Wnt signaling pathway | ossification | vesicle localization | positive regulation of lipid metabolic process | cellular metabolic process | body morphogenesis | regulation of protein localization | regulation of cell death | sex differentiation | regulation of smooth muscle cell proliferation | response to carbohydrate | circulatory system development | carbohydrate homeostasis | positive regulation of nucleocytoplasmic transport | regulation of triglyceride biosynthetic process | negative regulation of cell differentiation | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | face development

GO Cellular Component

nuclear transcription factor complex | chromosome | catenin-TCF7L2 complex | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | protein-DNA complex | nucleoplasm | chromatin | nuclear chromosome | beta-catenin-TCF7L2 complex | beta-catenin-TCF complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular