QuickView for TIMP-2;jsessionid=54416DEE4D538EE9DC7ACB636E5351F8;jsessionid=772F0BCF3A3892FBCFF655A0B310047E (gene)
- Gene Symbol:
- Timp2
Rattus norvegicus - Full name:
- TIMP metallopeptidase inhibitor 2
- Synonyms:
- metalloproteinase inhibitor 2, TIMP-2, tissue inhibitor of metalloproteinase 2, tissue inhibitor of metalloproteinases 2
- Genomic Location:
- Chr 10: 108310473-108358821
- Description:
-
acts as an inhibitor of metallopeptidase activity; may play a role in tissue remodeling during spermatogenesis
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
endopeptidase inhibitor activity | enzyme activator activity | cation binding | enzyme binding | protein-containing complex binding | enzyme inhibitor activity | signaling receptor binding | molecular function regulator | ion binding | integrin binding | cell adhesion molecule binding | protein binding | zinc ion binding | transition metal ion binding | metalloendopeptidase inhibitor activity | peptidase inhibitor activity | enzyme regulator activity | protease binding | metal ion binding
GO Biological Process
positive regulation of cyclase activity | negative regulation of membrane protein ectodomain proteolysis | endopeptidase inhibitor activity | response to cytokine | regulation of neurogenesis | positive regulation of lyase activity | enzyme activator activity | regulation of cell development | response to hormone | negative regulation of cellular process | positive regulation of developmental process | cell differentiation | male gamete generation | nervous system development | response to drug | neurogenesis | positive regulation of phosphate metabolic process | generation of neurons | negative regulation of proteolysis | cellular process | negative regulation of signaling | multicellular organismal reproductive process | regulation of proteolysis | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | gamete generation | regulation of cellular process | regulation of metabolic process | positive regulation of cellular protein metabolic process | response to stimulus | enzyme inhibitor activity | positive regulation of protein metabolic process | regulation of cell proliferation | reproduction | negative regulation of metabolic process | molecular function regulator | system development | reproductive process | regulation of signal transduction | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | regulation of MAPK cascade | regulation of catalytic activity | regulation of phosphorylation | negative regulation of peptidase activity | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | negative regulation of metallopeptidase activity | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of intracellular signal transduction | positive regulation of cell differentiation | positive regulation of adenylate cyclase activity | regulation of cellular protein metabolic process | regulation of cyclase activity | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of mitotic cell cycle | positive regulation of molecular function | multicellular organism reproduction | regulation of Rap protein signal transduction | positive regulation of protein modification process | response to organic substance | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | positive regulation of neurogenesis | positive regulation of cell development | regulation of protein catabolic process | negative regulation of mitotic cell cycle | negative regulation of cellular protein metabolic process | negative regulation of small GTPase mediated signal transduction | negative regulation of Ras protein signal transduction | regulation of phosphate metabolic process | positive regulation of MAPK cascade | regulation of adenylate cyclase activity | negative regulation of cell cycle | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | metalloendopeptidase inhibitor activity | positive regulation of phosphorylation | peptidase inhibitor activity | enzyme regulator activity | regulation of Ras protein signal transduction | regulation of endopeptidase activity | regulation of nervous system development | regulation of developmental process | developmental process | spermatogenesis | negative regulation of cell proliferation | negative regulation of hydrolase activity | central nervous system development | positive regulation of metabolic process | positive regulation of neuron differentiation | cellular response to organic substance | aging | sexual reproduction | positive regulation of signaling | regulation of signaling | negative regulation of endopeptidase activity | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | neuron projection | extracellular matrix | basement membrane | somatodendritic compartment | cell body | cell | neuronal cell body | distal axon | collagen-containing extracellular matrix | intracellular organelle | cell projection | site of polarized growth | extracellular region | membrane-bounded organelle | nucleus | organelle | extracellular space | axon | growth cone | cell surface | intracellular
