QuickView for TNFSF4;jsessionid=48582D5F81AEBB11C49122368C01EDDA;jsessionid=4D3DCAFD2C0DFBDB2E0E8149FCDB3180;jsessionid=3930F8EA44DBCA030D5CE5318E306B81;jsessionid=B00440D5E0C9C2AAB510E70F41A69001;jsessionid=05326689BB69FA296F1029E6CE92A1A7 (gene)
- Gene Symbol:
- Tnfsf4
Rattus norvegicus - Full name:
- TNF superfamily member 4
- Synonyms:
- Ox40l, Tnlg2b, tumor necrosis factor ligand superfamily member 4, OX40 ligand, tumor necrosis factor (ligand) superfamily, member 4, tumor necrosis factor ligand 2b, tumor necrosis factor superfamily member 4
- Genomic Location:
- Chr 13: 77026337-77050223
- Description:
-
ligand for the tumor necrosis factor receptor OX40 (CD134); exhibits costimulatory activity for T-cell proliferation
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
EVI1_04 , AP4_Q6 , NFKB_Q6 , AML1_01 , FOXO4_01 , FOXO4_02 , CTGRYYYNATT_UNKNOWN , CRX_Q4 , COREBINDINGFACTOR_Q6 , HMGIY_Q6
- miRNA binding sites
(Source: TargetScan):
GO Molecular Function
signaling receptor binding | cytokine receptor binding | molecular function regulator | tumor necrosis factor receptor binding | protein binding | receptor regulator activity | receptor ligand activity | cytokine activity | tumor necrosis factor receptor superfamily binding
GO Biological Process
positive regulation of immune response | negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | regulation of T cell mediated immunity | response to virus | negative regulation of immune system process | cellular response to nitrogen dioxide | regulation of B cell activation | CD4-positive, alpha-beta T cell activation | response to lipopolysaccharide | negative regulation of peptide secretion | regulation of localization | defense response to other organism | regulation of immune system process | response to hormone | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | positive regulation of developmental process | negative regulation of RNA biosynthetic process | positive regulation of lymphocyte activation | regulation of T cell differentiation | defense response | lymphocyte costimulation | positive regulation of DNA recombination | positive regulation of cell adhesion | negative regulation of protein secretion | positive regulation of protein secretion | positive regulation of T cell differentiation | negative regulation of T-helper 1 cell differentiation | positive regulation of CD4-positive, alpha-beta T cell costimulation | sterol metabolic process | regulation of immunoglobulin secretion | cellular process | positive regulation of immune effector process | positive regulation of memory T cell differentiation | positive regulation of adaptive immune response | negative regulation of nucleic acid-templated transcription | negative regulation of alpha-beta T cell differentiation | negative regulation of secretion | CD4-positive, alpha-beta T cell costimulation | positive regulation of nitrogen compound metabolic process | response to inorganic substance | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of CD4-positive, alpha-beta T cell activation | response to prostaglandin | regulation of immune response | regulation of cellular process | leukocyte activation | cellular response to lipid | regulation of metabolic process | cellular response to prostaglandin stimulus | negative regulation of cytokine secretion | positive regulation of activated T cell proliferation | cellular response to molecule of bacterial origin | positive regulation of interferon-gamma production | organic cyclic compound metabolic process | positive regulation of T cell costimulation | regulation of type 2 immune response | positive regulation of T cell cytokine production | positive regulation of interleukin-4 production | T cell activation | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | regulation of DNA recombination | regulation of regulatory T cell differentiation | chemokine (C-C motif) ligand 11 production | positive regulation of immune system process | negative regulation of cell adhesion | regulation of CD4-positive, alpha-beta T cell activation | mononuclear cell proliferation | positive regulation of immunoglobulin production | response to stress | negative regulation of lymphocyte activation | positive regulation of lymphocyte proliferation | alcohol metabolic process | regulation of cell proliferation | negative regulation of interferon-gamma production | positive regulation of T-helper 2 cell activation | positive regulation of cell-cell adhesion | positive regulation of cell activation | cellular response to inorganic substance | response to alcohol | response to molecule of bacterial origin | positive regulation of T cell activation | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | negative regulation of hemopoiesis | regulation of peptide transport | regulation of cell adhesion | molecular function regulator | regulation of lymphocyte differentiation | negative regulation of adaptive immune response | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | positive regulation of mononuclear cell proliferation | response to external biotic stimulus | regulation of interleukin-4 production | regulation of signal transduction | negative regulation of secretion by cell | negative regulation of T-helper cell differentiation | positive regulation of lymphocyte differentiation | positive regulation of inflammatory response | response to fatty acid | lipid metabolic process | positive regulation of isotype switching to IgE isotypes | regulation of CD4-positive, alpha-beta T cell differentiation | regulation of T cell activation | cellular response to prostaglandin E stimulus | positive regulation of alpha-beta T cell differentiation | regulation of activated T cell proliferation | regulation of gene expression | response to prostaglandin E | positive regulation of secretion | response to ketone | response to lipid | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | small molecule metabolic process | positive regulation of interleukin-12 production | negative regulation of DNA-binding transcription factor activity | positive regulation of T-helper 2 cell differentiation | positive regulation of interleukin-13 production | negative regulation of interleukin-17 production | memory T cell activation | positive regulation of cell differentiation | regulation of T cell cytokine production | cell proliferation | leukocyte proliferation | negative regulation of T-helper 1 type immune response | positive regulation of immunoglobulin mediated immune response | positive regulation of T cell proliferation | negative regulation of immune response | T-helper 2 cell activation | defense response to nematode | positive regulation of isotype switching | response to bacterium | negative regulation of cell-cell adhesion | regulation of cellular metabolic process | regulation of alpha-beta T cell differentiation | negative regulation of cell activation | inflammatory response | regulation of cytokine production involved in immune response | positive regulation of cell proliferation | positive regulation of establishment of protein localization | negative regulation of CD4-positive, alpha-beta T cell differentiation | regulation of RNA metabolic process | positive regulation of interleukin-4-dependent isotype switching to IgE isotypes | positive regulation of B cell activation | positive regulation of transport | cellular response to fatty acid | negative regulation of T cell differentiation | lymphocyte activation | response to nitrogen dioxide | regulation of cytokine secretion | cytokine production | regulation of signaling receptor activity | receptor regulator activity | regulation of establishment of protein localization | positive regulation of type 2 immune response | positive regulation of T-helper cell differentiation | response to organic substance | regulation of hemopoiesis | chemokine production | regulation of DNA-binding transcription factor activity | metabolic process | regulation of isotype switching | regulation of adaptive immune response | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | cholesterol metabolic process | negative regulation of transcription, DNA-templated | positive regulation of cytokine production involved in immune response | positive regulation of memory T cell activation | regulation of secretion | receptor ligand activity | positive regulation of interleukin-6 production | immune response | cytokine activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | T cell proliferation | regulation of cell activation | regulation of protein secretion | alpha-beta T cell activation | positive regulation of cytokine production | cell activation | positive regulation of T cell mediated immunity | positive regulation of protein transport | regulation of T-helper cell differentiation | steroid metabolic process | T cell costimulation | lymphocyte proliferation | regulation of cell communication | positive regulation of interleukin-10 production | regulation of T-helper 1 cell differentiation | negative regulation of molecular function | regulation of immunoglobulin production | regulation of transcription, DNA-templated | regulation of T cell proliferation | positive regulation of CD4-positive, alpha-beta T cell differentiation | regulation of cytokine production | response to biotic stimulus | regulation of developmental process | positive regulation of DNA metabolic process | positive regulation of immunoglobulin secretion | positive regulation of alpha-beta T cell activation | negative regulation of alpha-beta T cell activation | positive regulation of interleukin-2 production | regulation of transport | regulation of cell-cell adhesion | positive regulation of metabolic process | acute inflammatory response | regulation of interferon-gamma production | immune system process | cellular response to organic substance | regulation of protein localization | positive regulation of CD4-positive, alpha-beta T cell activation | regulation of interleukin-6 production | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | negative regulation of cell differentiation | regulation of memory T cell differentiation | response to other organism | regulation of signaling | negative regulation of regulatory T cell differentiation | cellular response to lipopolysaccharide | multicellular organismal process
GO Cellular Component
integral component of membrane | cell | intrinsic component of membrane | extracellular region | extracellular space | cell surface | membrane
