QuickView for TRP63 (gene)

GO Molecular Function

sequence-specific DNA binding | WW domain binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | chromatin binding | protein domain specific binding | p53 binding | DNA binding | MDM2/MDM4 family protein binding | identical protein binding | damaged DNA binding | organic cyclic compound binding | protein binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | limb development | protein homooligomerization | positive regulation of macromolecule biosynthetic process | prostatic bud formation | regulation of cysteine-type endopeptidase activity | cranial skeletal system development | developmental process involved in reproduction | muscle tissue development | intracellular signal transduction | positive regulation of apoptotic process | morphogenesis of an epithelium | regulation of programmed cell death | neuron death | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of mesoderm development | positive regulation of developmental process | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | positive regulation of fibroblast apoptotic process | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | limb morphogenesis | negative regulation of signaling | reproductive system development | mesoderm development | negative regulation of nucleic acid-templated transcription | glandular epithelial cell differentiation | negative regulation of apoptotic process | digestive tract morphogenesis | regulation of proteolysis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | intrinsic apoptotic signaling pathway | autonomic nervous system development | hindlimb morphogenesis | morphogenesis of a polarized epithelium | regulation of cellular process | regulation of osteoblast differentiation | regulation of apoptotic process | regulation of metabolic process | polarized epithelial cell differentiation | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | cellular component organization | prostate gland epithelium morphogenesis | regulation of cell division | urogenital system development | regulation of keratinocyte proliferation | response to stimulus | embryonic limb morphogenesis | skin morphogenesis | gland morphogenesis | response to stress | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of epidermal cell division | multicellular organismal homeostasis | tube morphogenesis | epithelial cell development | regulation of epithelial cell differentiation | cloaca development | programmed cell death | positive regulation of somatic stem cell population maintenance | reproduction | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development | cellular nitrogen compound metabolic process | regulation of stem cell population maintenance | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | cellular biosynthetic process | embryo development | cell-cell signaling | regulation of nucleic acid-templated transcription | water homeostasis | apoptotic process | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | keratinocyte proliferation | multicellular organism development | regulation of peptidase activity | female genitalia morphogenesis | epithelial cell differentiation involved in prostate gland development | cellular response to DNA damage stimulus | protein complex oligomerization | positive regulation of keratinocyte proliferation | regulation of catalytic activity | regulation of intracellular estrogen receptor signaling pathway | regulation of ossification | cloacal septation | regulation of gene expression | lateral sprouting from an epithelium | forelimb morphogenesis | cellular response to stress | regulation of epidermis development | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of keratinocyte differentiation | positive regulation of Notch signaling pathway | regulation of nitrogen compound metabolic process | embryonic forelimb morphogenesis | regulation of Notch signaling pathway | neuron apoptotic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of transcription by RNA polymerase II | protein homotetramerization | morphogenesis of an epithelial fold | positive regulation of cell differentiation | negative regulation of epidermal cell differentiation | epidermal cell differentiation | stem cell differentiation | epidermal cell division | negative regulation of intracellular steroid hormone receptor signaling pathway | cell proliferation | biosynthetic process | cell division | aromatic compound biosynthetic process | positive regulation of ossification | digestive tract development | protein tetramerization | epidermis development | regulation of apoptotic signaling pathway | skin development | keratinocyte differentiation | proximal/distal pattern formation | animal organ formation | cell communication | regulation of cellular metabolic process | chromatin remodeling | female genitalia development | sympathetic nervous system development | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of RNA metabolic process | genitalia development | establishment of planar polarity | negative regulation of intracellular estrogen receptor signaling pathway | apoptotic signaling pathway | cell aging | embryonic hindlimb morphogenesis | embryonic morphogenesis | negative regulation of epithelial cell differentiation | smooth muscle tissue development | positive regulation of osteoblast differentiation | protein-containing complex assembly | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | regulation of mesoderm development | DNA-binding transcription factor activity | regionalization | gland development | tissue morphogenesis | digestive system development | epithelial cell proliferation | post-anal tail morphogenesis | establishment of tissue polarity | anatomical structure development | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | chemical homeostasis | positive regulation of cell death | morphogenesis of embryonic epithelium | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | regulation of water loss via skin | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of programmed cell death | skin epidermis development | genitalia morphogenesis | prostate gland morphogenesis | negative regulation of keratinocyte differentiation | intrinsic apoptotic signaling pathway by p53 class mediator | transcription, DNA-templated | morphogenesis of a branching epithelium | anatomical structure formation involved in morphogenesis | multicellular organism aging | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cell development | regulation of epithelial cell proliferation | morphogenesis of a branching structure | anatomical structure morphogenesis | prostate gland development | regulation of endopeptidase activity | cellular macromolecule biosynthetic process | positive regulation of stem cell population maintenance | reproductive structure development | establishment of skin barrier | regulation of developmental process | regulation of mesenchymal cell proliferation | developmental process | organelle organization | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of mesenchymal cell proliferation | multicellular organismal water homeostasis | positive regulation of nucleic acid-templated transcription | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of fibroblast apoptotic process | ectoderm and mesoderm interaction | positive regulation of metabolic process | chromosome organization | skeletal system development | cellular metabolic process | female sex differentiation | regulation of cell death | sex differentiation | signal transduction by p53 class mediator | negative regulation of cell death | aging | negative regulation of cell differentiation | regulation of epidermal cell differentiation | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | Golgi apparatus | endomembrane system | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | intracellular

PATHWAYS

PID_P73PATHWAY | PID_P53_DOWNSTREAM_PATHWAY | PID_DELTA_NP63_PATHWAY | PID_TAP63_PATHWAY

PROTEIN FAMILY

Sterile alpha motif domain | p53 tumour suppressor family | p53-like transcription factor, DNA-binding | p53, tetramerisation domain | p53, DNA-binding domain | p53/RUNT-type transcription factor, DNA-binding domain superfamily | Sterile alpha motif/pointed domain superfamily | Tumour protein p63 | p53-like tetramerisation domain superfamily | Tumour protein p63, SAM domain