QuickView for Tpm-2;jsessionid=CE67D50936C7832BA659B5B0F1021DF1;jsessionid=26094B3E16F6AE349AA108EACBFF8E10;jsessionid=7824D90E5746AC2CB272A705262C7DBC;jsessionid=0A8286C640C52BFFF980148874483DD8;jsessionid=7E1C870ADFFA2FE6ABE4485874FA0BCB;jsessionid=CA31DE319883BF5EF4A108CE54E8AF49;jsessionid=5AE1833F6E6ABBFC0028248B18FECB68 (gene)
- Gene Symbol:
- TPM2
Homo sapiens - Full name:
- tropomyosin 2
- Synonyms:
- AMCD1, DA1, DA2B, HEL-S-273, NEM4, TMSB, tropomyosin beta chain, epididymis secretory protein Li 273, nemaline myopathy type 4, tropomyosin 2 (beta)
- Genomic Location:
- Chr 9: 35671990-35680053
- Description:
-
This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript varian...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
9p13.3
GO Molecular Function
structural molecule activity | actin binding | actin filament binding | protein-containing complex binding | cytoskeletal protein binding | identical protein binding | protein heterodimerization activity | protein binding | protein homodimerization activity | protein dimerization activity | structural constituent of muscle
GO Biological Process
actin filament-based process | actin cytoskeleton organization | cellular process | actin filament-based movement | cellular component organization | actin-mediated cell contraction | muscle contraction | actin-myosin filament sliding | regulation of ATPase activity | supramolecular fiber organization | actin filament organization | regulation of catalytic activity | muscle filament sliding | cytoskeleton organization | organelle organization | muscle system process | multicellular organismal process
GO Cellular Component
supramolecular fiber | sarcomere | muscle thin filament tropomyosin | cell | myofibril | cytoplasm | striated muscle thin filament | intracellular organelle | actin cytoskeleton | contractile fiber | organelle | cytosol | actin filament | cytoskeleton | intracellular | supramolecular complex
