QuickView for VHL;jsessionid=A28B488ABA6FCB52D5597AB6D993FFA5;jsessionid=D4FB02805AEEC523B3B85F3064DF287B (gene)
- Gene Symbol:
- Vhl
Rattus norvegicus - Full name:
- von Hippel-Lindau tumor suppressor
- Synonyms:
- Vhlh, von Hippel-Lindau disease tumor suppressor, pVHL, von Hippel-Lindau protein, von Hippel-Lindau syndrome homolog, von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- Genomic Location:
- Chr 4: 149529396-149536289
- Description:
-
may act as a tumor suppressor
- Orthologs:
- Homo sapiens , Mus musculus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
GO Molecular Function
enzyme binding | protein-containing complex binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | protein binding | transcription factor binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity
GO Biological Process
ciliary body morphogenesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | extracellular structure organization | cell motility | NLS-bearing protein import into nucleus | regulation of cellular localization | proteolysis | homeostasis of number of cells within a tissue | regulation of localization | regulation of programmed cell death | eye development | establishment of localization | blood vessel endothelial cell migration | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | response to drug | type B pancreatic cell differentiation | epithelial cell migration | neurogenesis | generation of neurons | response to antibiotic | tissue homeostasis | intracellular transport | phenol-containing compound metabolic process | blood vessel morphogenesis | melanin metabolic process | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | protein transport | negative regulation of signaling | epithelium migration | eye pigmentation | negative regulation of nucleic acid-templated transcription | macromolecule localization | glandular epithelial cell differentiation | negative regulation of apoptotic process | response to hypoxia | positive regulation of nitrogen compound metabolic process | establishment of localization in cell | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | anatomical structure homeostasis | regulation of lymphocyte apoptotic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | protein import into nucleus | organic cyclic compound metabolic process | epithelium development | cellular aromatic compound metabolic process | endocrine pancreas development | cellular component organization | response to stimulus | vasculature development | regulation of cellular protein localization | negative regulation of T cell apoptotic process | cellular response to hypoxia | negative regulation of JAK-STAT cascade | response to stress | intracellular protein transport | endothelial cell migration | regulation of cell proliferation | multicellular organismal homeostasis | tube morphogenesis | protein localization to nucleus | regulation of epithelial cell differentiation | cellular protein catabolic process | cellular localization | response to alcohol | cardiovascular system development | proteasomal protein catabolic process | extracellular matrix organization | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | macromolecule modification | blood vessel development | response to ethanol | regulation of catecholamine metabolic process | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | locomotion | organic hydroxy compound metabolic process | system development | response to oxygen levels | nitrogen compound metabolic process | enteroendocrine cell differentiation | regulation of signal transduction | regulation of cellular response to hypoxia | multicellular organism development | cell migration | protein complex oligomerization | regulation of gene expression | pancreas development | organic substance transport | cellular response to stress | protein catabolic process | negative regulation of hypoxia-inducible factor-1alpha signaling pathway | positive regulation of cellular metabolic process | animal organ morphogenesis | developmental pigmentation | negative regulation of lymphocyte apoptotic process | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | peptide transport | regulation of transcription by RNA polymerase II | pigmentation | ubiquitin protein ligase activity | protein localization to organelle | import into nucleus | homeostasis of number of cells | angiogenesis | response to toxic substance | regulation of apoptotic signaling pathway | negative regulation of transcription from RNA polymerase II promoter in response to hypoxia | endocrine system development | sensory organ development | negative regulation of endothelial cell differentiation | protein import | regulation of cellular metabolic process | eye morphogenesis | regulation of T cell apoptotic process | pancreatic A cell differentiation | homeostatic process | positive regulation of cell proliferation | regulation of RNA metabolic process | negative regulation of epithelial cell differentiation | negative regulation of thymocyte apoptotic process | neuron differentiation | protein-containing complex assembly | protein metabolic process | response to organic substance | protein ubiquitination | regulation of JAK-STAT cascade | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | establishment of protein localization to organelle | anatomical structure development | metabolic process | regulation of DNA-templated transcription in response to stress | ubiquitin-protein transferase activity | regulation of thymocyte apoptotic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | cellular protein localization | amide transport | organic substance metabolic process | nuclear transport | negative regulation of biosynthetic process | negative regulation of gene expression | pigment metabolic process | animal organ development | retina homeostasis | negative regulation of transcription from RNA polymerase II promoter in response to stress | protein modification by small protein conjugation or removal | establishment of protein localization | camera-type eye development | anatomical structure formation involved in morphogenesis | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | protein localization | regulation of epithelial cell proliferation | negative regulation of leukocyte apoptotic process | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | protein heterooligomerization | anatomical structure morphogenesis | cellular macromolecule localization | camera-type eye morphogenesis | nucleocytoplasmic transport | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | cellular protein modification process | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of endothelial cell differentiation | positive regulation of nucleic acid-templated transcription | epithelial cell differentiation | positive regulation of metabolic process | cellular metabolic process | ameboidal-type cell migration | regulation of protein localization | regulation of cell death | homeostasis of number of retina cells | negative regulation of cell death | circulatory system development | negative regulation of cell differentiation | negative regulation of cellular response to hypoxia | regulation of signaling | positive regulation of gene expression | iris morphogenesis | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
Cul2-RING ubiquitin ligase complex | intracellular membrane-bounded organelle | catalytic complex | VCB complex | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | cell projection | nucleoplasm | cilium | transferase complex | mitochondrion | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | cytoplasmic ubiquitin ligase complex | membrane
