QuickView for Vph1p;jsessionid=879D8BC11124208CAF2793D6CD27410E;jsessionid=CD2D123A251C6ECF6CEC8E2FA21FA450 (gene)

Gene Symbol:

ATP6V0A1 Homo sapiens

Full name:

ATPase H+ transporting V0 subunit a1

Synonyms:

ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1, V-type proton ATPase 116 kDa subunit a isoform 1, V-type proton ATPase 116 kDa subunit a, ATPase, H+ transporting, lysosomal V0 subunit a1, ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD), H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1, V-ATPase 116 kDa, clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit, vacuolar adenosine triphosphatase subunit Ac116, vacuolar proton pump subunit 1, vacuolar proton translocating ATPase 116 kDa subunit A, vacuolar-type H(+)-ATPase 115 kDa subunit

Genomic Location:

Chr 17: 37864388-37928123

Description:

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient ge...

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This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  AML_Q6 ,  OSF2_Q6 ,  NRSF_01 ,  PAX4_02 ,  LMO2COM_02 ,  OCT1_03 ,  CTTTAAR_UNKNOWN ,  NRF2_Q4 ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  CCTNTMAGA_UNKNOWN ,  TCF11MAFG_01

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Cytogenetic Map:

17q21.2

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