QuickView for dsirt2;jsessionid=F67158940E90BADC7CE22F60D85A06EB;jsessionid=A136FA6F0DEEBAF99C62E3539C4E0B90;jsessionid=0FB55E82A013AD947833BD851C01386A (gene)
- Gene Symbol:
- HST2
Saccharomyces cerevisiae - Full name:
- Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
- Synonyms:
- HST2, HST2, YPL015C
- Genomic Location:
- Chr XVI: 525807-526880
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , Schizosaccharomyces pombe , Danio rerio , Pan troglodytes , Bos taurus , Gallus gallus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
cofactor binding | cation binding | nucleotide binding | coenzyme binding | hydrolase activity | protein deacetylase activity | NAD+ binding | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | histone deacetylase activity | ion binding | organic cyclic compound binding | NAD-dependent histone deacetylase activity | zinc ion binding | NAD binding | transition metal ion binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
RNA metabolic process | positive regulation of macromolecule biosynthetic process | regulation of chromatin silencing at telomere | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | histone deacetylation | regulation of organelle organization | negative regulation of DNA metabolic process | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cellular process | gene silencing | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | regulation of DNA recombination | cellular nitrogen compound biosynthetic process | regulation of gene silencing | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | protein deacetylase activity | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | NAD-dependent protein deacetylase activity | regulation of gene expression | histone deacetylase activity | negative regulation of gene expression, epigenetic | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | positive regulation of gene expression, epigenetic | biosynthetic process | protein deacetylation | aromatic compound biosynthetic process | NAD-dependent histone deacetylase activity | regulation of cellular metabolic process | chronological cell aging | regulation of RNA metabolic process | cell aging | negative regulation of gene silencing | protein metabolic process | metabolic process | negative regulation of chromatin silencing | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of mitotic recombination | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | chromatin silencing at rDNA | regulation of chromosome organization | transcription, DNA-templated | negative regulation of DNA recombination | negative regulation of chromatin silencing at telomere | negative regulation of chromosome organization | negative regulation of mitotic recombination | covalent chromatin modification | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular macromolecule biosynthetic process | developmental process | organelle organization | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | chromatin silencing | cellular metabolic process | aging | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | regulation of chromatin organization
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | membrane-bounded organelle | nucleus | organelle | intracellular
