QuickView for ERLIN2 (gene)

1. The erlin2 T65I mutation inhibits erlin1/2 complex-mediated inositol 1,4,5-trisphosphate receptor ub…
2. Binding of the erlin1/2 complex to the third intralumenal loop of IP3R1 triggers its ubiquitin-prote…
3. Erlin-2 is associated with active γ-secretase in brain and affects amyloid β-peptide production.
4. EVI/WLS function is regulated by ubiquitination and linked to ER-associated degradation by ERLIN2.
5. An autosomal dominant ERLIN2 mutation leads to a pure HSP phenotype distinct from the autosomal rece…

There were no clinical trials for ERLIN2