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Arachidonate 5- Lipoxygenase
Summary
General Info
Curated Studies
Most Correlated Studies
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (3 of 4)
Broad Connectivity Map (CMAP 2.0) compound database
Drug target sets for approved compounds
Ventral prostates from 15-LOX2 transgenic mice
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Literature
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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape.
ALOX5 drives the pyroptosis of CD4+ T cells and tissue inflammation in rheumatoid arthritis.
Osteomesopyknosis associated with a novel ALOX5 variant that impacts the RANKL pathway.
Structure and ligand based design for identification of highly potent molecules against 5-LOX.
ALOX5-mediated ferroptosis acts as a distinct cell death pathway upon oxidative stress in Huntington…
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Clinical Trials
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Study of the Arachidonate 5-Lipoxygenase Enzyme in Affecting the Risk for Coronary Heart Disease
The Role of Arachidonic Acid Metabolites, From Patients With Metabolic Syndrome
Fish Oil to Prevent Asthma Exacerbations in Patients With ALOX5 Polymorphisms
Safety of Zileuton (Zyflo) in Combination With Imatinib Mesylate (Gleevec) in CML.
Heart & Health Study
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