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QuickView for Simvastatin (compound)


Genetic Markers

Most Correlated Genes

  1. EHHADH
  2. Acot1
  3. HMGCR
  4. PDK4
  5. NFE2
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Pathway Enrichment

Most Correlated Biogroups

  1. PILON_KLF1_TARGETS_DN
  2. organic cyclic compound metabolic process
  3. heterocyclic compound binding
  4. organic cyclic compound binding
  5. DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP
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Curated Studies

Most Correlated Studies

  1. Genomics Assisted Toxicity Evaluation system study - Human Hepatocytes
  2. Peripheral atherosclerosis plaques after simvastatin, losartan or pioglitazone treatment
  3. EBV-transformed and native B-cells treated with statins
  4. Cortical neurons exposed to excitotoxic NMDA and potentially neuroprotective compounds
  5. Umbilical vein endothelial cells overexpressing EZH2 treated with simvastatin
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Literature

Most Relevant Literature

  1. Niosomal delivery of simvastatin to MDA-MB-231 cancer cells.
  2. Transgenerational inheritance of chemical-induced signature: A case study with simvastatin.
  3. Simvastatin affects Nrf2/MAPK signaling pathway and hepatic histological structure change in Gambusi…
  4. Simvastatin ointment in the treatment of seven childhood diffuse plane xanthomas.
  5. Effect of simvastatin on bovine intramuscular and subcutaneous adipocytes proliferation and gene exp…
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Clinical Trials

Most Relevant Clinical Trials

  1. The DDI Study of SP2086 and Simvastatin
  2. 7-day Simvastatin and Emotional Processing
  3. Sarilumab Effect on the Pharmacokinetics of Simvastatin
  4. Simvastatin in Chronic Obstructive Pulmonary Disease (COPD)
  5. Simvastatin for mTBI
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