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kdm2b protein, mouse
(compound)
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Genetic Markers
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Embryonic stem cell line E14 with shRNA-mediated knockdown of KDM2B
Embryonic stem cell line MS12 with tamoxifen-induced KDM2B-knockout
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Literature
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Polycomb complex recruitment in pluripotent stem cells.
Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in rep…
Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells…
Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly.
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