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response to misfolded protein
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General Info
Body Atlas
Most Correlated Tissues
Colon cecum
Ovary
Cervix
Liver
Vagina
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Disease Atlas
Most Correlated Diseases
Alpha-1-antitrypsin deficiency
Disorder of digestive system
Pyloric ulcer
Multiple-resistant Staphylococcus aureus infection
Hemorrhagic shock
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Pharmaco Atlas
Most Correlated Compounds
niguldipine
CGP 60474
GSK-1059615
sitagliptin
AT 7867
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Knockdown Atlas
Most Correlated Gene Perturbations
CCDC170
IRF7
HSPA9
AXL
DROSHA
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Curated Studies
Most Correlated Studies
L1000 CMAP - Prostate cancer PC3.101 cells with CRISPR-targeted gene knockouts
L1000 CMAP - Breast cancer MCF7 cells treated with small molecule perturbagens (1 of 4)
Calu-3 lung adenocarcinoma cells infected with wildtype and mutant SARS virus
Dendritic cells infected with M. tuberculosis
L1000 CMAP - Adipocyte ASC cells treated with small molecule perturbagens
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Literature
Most Relevant Literature
Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins.
Oligomerization in endoplasmic reticulum stress signaling.
Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome …
Protein kinase CK2 regulates the formation and clearance of aggresomes in response to stress.
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein r…
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Clinical Trials
Most Relevant Clinical Trials
Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by …
Ambroxol Therapy for Patients With Type 1 Gaucher Disease and Suboptimal Response to Enzyme Replacem…
A Multicenter, Double-Blind Study to Investigate the Safety and Efficacy of Arimoclomol in Volunteer…
A Multicenter, Dose Ranging Safety and Pharmacokinetics Study of Arimoclomol in ALS
Study of Rifampicin in Multiple System Atrophy
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