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Restoring functions of tumor suppressors with small molecules.
Inese Smukste, Brent R Stockwell
Cancer cell 2003 Dec
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Developing small molecule inhibitors of oncoproteins, which are activated in tumor cells, is a newly popular strategy for cancer-related drug discovery. The complementary strategy, developing small molecules that restore the function of missing tumor suppressors, is much more difficult to realize. However, in this issue of Cancer Cell, Kau et al. report the discovery of small molecules that reverse some cellular consequences of the loss of the tumor suppressor PTEN.
Citation
Inese Smukste, Brent R Stockwell.
Restoring functions of tumor suppressors with small molecules.
Cancer cell.
2003 Dec;4(6):419-20
Mesh Tags
Active Transport, Cell Nucleus
Animals
Anticarcinogenic Agents
DNA-Binding Proteins
Fish Proteins
Forkhead Box Protein O1
Forkhead Transcription Factors
Humans
Karyopherins
Lipid Metabolism
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases
Phosphorylation
Protein Tyrosine Phosphatases
Receptors, Cytoplasmic and Nuclear
Transcription Factors
Tumor Suppressor Proteins
Exportin 1 Protein
Substances
Anticarcinogenic Agents
DNA-Binding Proteins
FOXO1 protein, human
Fish Proteins
Forkhead Box Protein O1
Forkhead Transcription Factors
Karyopherins
Receptors, Cytoplasmic and Nuclear
Transcription Factors
Tumor Suppressor Proteins
Phosphatidylinositol 3-Kinases
Protein Tyrosine Phosphatases
PTEN Phosphohydrolase
Pten protein, pufferfish
PMID: 14706331
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