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Locked nucleic acid (LNA) is one of the most prominent nucleic acid analogues reported so far. We herein for the first time report cleavage by restriction endonuclease of LNA-modified DNA oligonucleotides. The experiments revealed that RsaI is an efficient enzyme capable of recognizing and cleaving LNA-modified DNA oligonucleotides. Furthermore, introduction of LNA nucleotides protects against cleavage by the restriction endonucleases PvuII, PstI, SacI, KpnI and EcoRI. Copyright © 2012 Elsevier Ltd. All rights reserved.


Lucile Crouzier, Camille Dubois, Jesper Wengel, Rakesh N Veedu. Cleavage and protection of locked nucleic acid-modified DNA by restriction endonucleases. Bioorganic & medicinal chemistry letters. 2012 Jul 15;22(14):4836-8

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PMID: 22727669

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