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Hydroxyacid dehydrogenases limit the conversion of α-keto acids into aroma compounds. Here we report that inactivation of the panE gene, encoding the α-hydroxyacid dehydrogenase activity in Lactococcus lactis, enhanced the formation of 3-methylbutanal and 3-methylbutanol. L. lactis IFPL953ΔpanE was an efficient strain producing volatile compounds related to cheese aroma.


Luz P Gómez de Cadiñanos, Tomás García-Cayuela, Mireille Yvon, M Carmen Martinez-Cuesta, Carmen Peláez, Teresa Requena. Inactivation of the panE gene in Lactococcus lactis enhances formation of cheese aroma compounds. Applied and environmental microbiology. 2013 Jun;79(11):3503-6

PMID: 23524675

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