Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus?

Anna Jaśkiewicz, Tomasz Domoradzki, Beata Pająk

International journal of molecular sciences 2020 Nov 04

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Muscle cachexia is one of the most critical unmet medical needs. Identifying the molecular background of cancer-induced muscle loss revealed a promising possibility of new therapeutic targets and new drug development. In this review, we will define the signal transducer and activator of transcription 3 (STAT3) protein's role in the tumor formation process and summarize the role of STAT3 in skeletal muscle cachexia. Finally, we will discuss a vast therapeutic potential for the STAT3-inhibiting single-agent treatment innovation that, as the desired outcome, could block tumor growth and generally prevent muscle cachexia.

Citation

Anna Jaśkiewicz, Tomasz Domoradzki, Beata Pająk. Targeting the JAK2/STAT3 Pathway-Can We Compare It to the Two Faces of the God Janus? International journal of molecular sciences. 2020 Nov 04;21(21)