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Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic.

Jeffrey R Strich, Marcos J Ramos-Benitez, Davide Randazzo, Sydney R Stein, Ashley Babyak, Richard T Davey, Anthony F Suffredini, Richard W Childs, Daniel S Chertow

The Journal of infectious diseases 2021 Mar 29


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    Neutrophil extracellular traps (NETs) contribute to immunothrombosis and have been associated with mortality in coronavirus disease 2019 (COVID-19). We stimulated donor neutrophils with plasma from patients with COVID-19 and demonstrated that R406 can abrogate the release of NETs. These data provide evidence for how fostamatinib may mitigate neutrophil-associated mechanisms contributing to COVID-19 immunopathogenesis. Published by Oxford University Press for the Infectious Diseases Society of America 2020.

    Citation

    Jeffrey R Strich, Marcos J Ramos-Benitez, Davide Randazzo, Sydney R Stein, Ashley Babyak, Richard T Davey, Anthony F Suffredini, Richard W Childs, Daniel S Chertow. Fostamatinib Inhibits Neutrophils Extracellular Traps Induced by COVID-19 Patient Plasma: A Potential Therapeutic. The Journal of infectious diseases. 2021 Mar 29;223(6):981-984

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    PMID: 33367731

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