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Platelet-derived growth factor receptor B (PDGFRB) gene rearrangements define a unique subgroup of myeloid and lymphoid neoplasms frequently associated with eosinophilia and characterized by high sensitivity to tyrosine kinase inhibition. To date, various PDGFRB/5q32 rearrangements, involving at least 40 fusion partners, have been reported. However, information on genomic and clinical features accompanying rearrangements of PDGFRB is still scarce. Here, we characterized a series of 14 cases with a myeloid neoplasm using cytogenetic, single nucleotide polymorphism array, and next-generation sequencing. We identified nine PDGFRB translocation partners, including the KAZN gene at 1p36.21 as a novel partner in a previously undescribed t(1;5)(p36;q33) chromosome change. In all cases, the PDGFRB recombination was the sole cytogenetic abnormality underlying the phenotype. Acquired somatic variants were mainly found in clinically aggressive diseases and involved epigenetic genes (TET2, DNMT3A, ASXL1), transcription factors (RUNX1 and CEBPA), and signaling modulators (HRAS). By using both cytogenetic and nested PCR monitoring to evaluate response to imatinib, we found that, in non-AML cases, a low dosage (100-200 mg) is sufficient to induce and maintain longstanding hematological, cytogenetic, and molecular remissions. © 2021. The Author(s).

Citation

Danika Di Giacomo, Martina Quintini, Valentina Pierini, Fabrizia Pellanera, Roberta La Starza, Paolo Gorello, Caterina Matteucci, Barbara Crescenzi, Paolo Fabio Fiumara, Marinella Veltroni, Erika Borlenghi, Francesco Albano, Fabio Forghieri, Monica Maccaferri, Francesca Bettelli, Mario Luppi, Antonio Cuneo, Giuseppe Rossi, Cristina Mecucci. Genomic and clinical findings in myeloid neoplasms with PDGFRB rearrangement. Annals of hematology. 2022 Feb;101(2):297-307

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PMID: 34859285

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