TREM2: A new player in the tumor microenvironment.

Martina Molgora, Yizhou A Liu, Marco Colonna, Marina Cella

Seminars in immunology 2023 May

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TREM2 is a myeloid cell receptor that has been extensively described in the context of neuroinflammation and neurodegenerative diseases. Recently, TREM2 emerged as a crucial regulator of macrophage function in tumors. TREM2-deficiency or blockade provide protection and promote the response to anti-PD1 in different murine models. In human tumors, TREM2-expressing macrophages are present in numerous cohorts and tumor types and are generally associated with immunosuppression and poor prognosis. Here, we provide an overview of the impact of TREM2 in tumors considering current literature, with a focus on both murine models and human cancer. Copyright © 2023 Elsevier Ltd. All rights reserved.

Citation

Martina Molgora, Yizhou A Liu, Marco Colonna, Marina Cella. TREM2: A new player in the tumor microenvironment. Seminars in immunology. 2023 May;67:101739