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QuickView for Azlocillin (compound)

Name: Azlocillin
PubChem Compound ID: 1548938
Description: A semisynthetic ampicillin-derived acylureido penicillin.
Molecular formula: C20H23N5O6S
Molecular weight: 461.493 g/mol
Name: Azlocillin
Name (isomeric): DB01061
Drug Type: small molecule
Description: A semisynthetic ampicillin-derived acylureido penicillin.
Azlocillin sodium salt; Azlocillinum [INN-Latin]; Azlocilina [INN-Spanish]; Azlocilline [INN-French]
Brand: Azlin, Bayer Brand of Azlocillin, Securopen
Category: Anti-Bacterial Agents, Penicillins
CAS number: 37091-66-0
Indication: For the treatment of infections caused by <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Haemophilus influenzae</i>.
Azlocillin, similar to mezlocillin and piperacillin, is an acylampicillin with an extended spectrum of activity and greater in vitro potency than the carboxy penicillins. Azlocillin demonstrates antibacterial activity against a broad spectrum of bacteria, including Pseudomonas aeruginosa, and, in contrast to most cephalosporins, exhibits act...
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Mechanism of Action: By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, azlocillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that azlocillin interferes with an autolysin inhibitor.
Absorption: Not significantly absorbed from the gastrointestinal tract.
Protein binding: 20 to 46% bound to plasma proteins
Biotransformation: Eliminated predominantly by renal mechanisms, but also undergoes biotransformation within body tissues and intraintestinal degradation by bowel bacteria, with high concentrations found in bile.
Half Life: Mean elimination half-life is 1.3 to 1.5 hours. Longer in neonates, and 2 to 6 hours in patients with renal impairment.
Affected organisms: Enteric bacteria and other eubacteria
Drug interaction:
Ethinyl EstradiolThis anti-infectious agent could decrease the effect of the oral contraceptive
DoxycyclinePossible antagonism of action
DemeclocyclinePossible antagonism of action
MinocyclinePossible antagonism of action
TetracyclinePossible antagonism of action