QuickView for BCL-2 (gene)
- Gene Symbol:
- BCL2
Gallus gallus - Full name:
- B-cell CLL/lymphoma 2
- Synonyms:
- bcl-2
- Genomic Location:
- Chr 2: 69060877-69147814
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
sequence-specific DNA binding | protein phosphatase 2A binding | channel regulator activity | passive transmembrane transporter activity | enzyme binding | nucleic acid binding | transmembrane transporter activity | molecular function regulator | protein domain specific binding | ubiquitin-like protein ligase binding | channel inhibitor activity | DNA binding | transporter activity | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | protein binding | protein homodimerization activity | death domain binding | protein phosphatase binding | transcription factor binding | ubiquitin protein ligase binding | BH3 domain binding | protein dimerization activity | channel activity | protease binding | phosphatase binding | BH domain binding | heterocyclic compound binding
GO Biological Process
positive regulation of immune response | leukocyte homeostasis | response to extracellular stimulus | brain development | positive regulation of striated muscle cell differentiation | response to radiation | cell morphogenesis | regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of cell cycle process | cellular response to glucose starvation | cellular response to decreased oxygen levels | positive regulation of locomotion | response to virus | response to nutrient levels | actin filament-based process | response to endoplasmic reticulum stress | protein dephosphorylation | release of cytochrome c from mitochondria | response to cytokine | regulation of B cell activation | regulation of neurogenesis | neuron projection morphogenesis | behavioral fear response | immune response-regulating signaling pathway | developmental process involved in reproduction | regulation of cellular localization | intracellular signal transduction | ovarian follicle development | positive regulation of skeletal muscle tissue development | regulation of cell development | homeostasis of number of cells within a tissue | regulation of localization | regulation of cell cycle G1/S phase transition | cell-substrate adhesion | morphogenesis of an epithelium | positive regulation of striated muscle tissue development | gonad development | regulation of programmed cell death | female gonad development | T cell lineage commitment | peptidyl-amino acid modification | eye development | defense response to other organism | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of osteoblast proliferation | regulation of immune system process | response to hormone | neuron death | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | CD8-positive, alpha-beta T cell differentiation | response to metal ion | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of melanocyte differentiation | adherens junction assembly | defense response | glomerulus development | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | cellular response to extracellular stimulus | response to drug | reactive oxygen species metabolic process | organ growth | cellular chemical homeostasis | cell part morphogenesis | regulation of G1/S transition of mitotic cell cycle | neurogenesis | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | generation of neurons | membrane organization | B cell differentiation | response to antibiotic | mesenchyme development | tissue homeostasis | phenol-containing compound metabolic process | regulation of neuron death | melanin metabolic process | focal adhesion assembly | cellular process | channel regulator activity | lymphocyte differentiation | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | epithelial tube morphogenesis | extrinsic apoptotic signaling pathway | positive regulation of neuron maturation | lymphoid progenitor cell differentiation | passive transmembrane transporter activity | regulation of mitochondrial membrane potential | negative regulation of signaling | developmental growth | positive regulation of peptidyl-serine phosphorylation | neuron development | negative regulation of G1/S transition of mitotic cell cycle | cell-substrate adherens junction assembly | reproductive system development | negative regulation of anoikis | negative regulation of retinal cell programmed cell death | immune system development | multicellular organismal reproductive process | renal tubule morphogenesis | regulation of striated muscle tissue development | negative regulation of apoptotic process | branching involved in ureteric bud morphogenesis | digestive tract morphogenesis | response to hypoxia | cellular response to starvation | regulation of cell cycle | positive regulation of catalytic activity | regulation of multicellular organism growth | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | gamete generation | positive regulation of muscle cell differentiation | anatomical structure homeostasis | cell junction assembly | intrinsic apoptotic signaling pathway | regulation of myotube differentiation | negative regulation of apoptotic signaling pathway | regeneration | response to hydrogen peroxide | negative regulation of cell motility | regulation of immune response | regulation of cellular process | leukocyte activation | positive regulation of cell growth | regulation of apoptotic process | regulation of skeletal muscle fiber development | regulation of metabolic process | transmembrane transporter activity | organic cyclic compound metabolic process | regulation of cell maturation | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | pons development | cellular component organization | calcium ion homeostasis | urogenital system development | T cell activation | nephron tubule morphogenesis | development of primary sexual characteristics | response to UV | head development | response to stimulus | peptidyl-threonine phosphorylation | thymus development | female gamete generation | cell morphogenesis involved in neuron differentiation | regulation of glycoprotein biosynthetic process | mesenchymal cell development | regulation of mitotic cell cycle phase transition | metencephalon development | positive regulation of immune system process | CD8-positive, alpha-beta T cell lineage commitment | positive regulation of protein metabolic process | negative regulation of myeloid cell apoptotic process | mononuclear cell proliferation | cellular response to hypoxia | gland morphogenesis | response to stress | germ cell development | positive regulation of lymphocyte proliferation | regulation of cell proliferation | multicellular organismal homeostasis | tube morphogenesis | regulation of cell cycle phase transition | positive regulation of B cell proliferation | response to starvation | hematopoietic progenitor cell differentiation | regulation of smooth muscle cell migration | regulation of protein homodimerization activity | pigment cell differentiation | programmed cell death | development of primary female sexual characteristics | supramolecular fiber organization | positive regulation of cell activation | regulation of developmental pigmentation | reproduction | response to ischemia | negative regulation of cellular pH reduction | immune response-activating signal transduction | negative regulation of transport | extrinsic apoptotic signaling pathway via death domain receptors | apoptotic mitochondrial changes | negative regulation of metabolic process | hemopoiesis | cellular component assembly | regulation of anoikis | protein modification process | regulation of cell adhesion | kidney development | positive regulation of multicellular organism growth | mitochondrion organization | response to iron ion | macromolecule modification | B cell receptor signaling pathway | molecular function regulator | metal ion homeostasis | regulation of membrane potential | leukocyte differentiation | organic hydroxy compound metabolic process | negative regulation of neuron apoptotic process | apoptotic process | regulation of calcium ion transport into cytosol | response to light stimulus | positive regulation of mononuclear cell proliferation | regulation of skeletal muscle tissue development | response to nicotine | response to external biotic stimulus | system development | cellular response to nutrient levels | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | ureteric bud development | negative regulation of growth | regulation of protein stability | channel inhibitor activity | adherens junction organization | multicellular organism development | pigment granule organization | phosphorus metabolic process | regulation of neuron maturation | actin filament organization | positive regulation of smooth muscle cell migration | positive regulation of skeletal muscle fiber development | cellular response to DNA damage stimulus | positive regulation of muscle organ development | spleen development | regulation of catalytic activity | cellular response to oxidative stress | oocyte differentiation | regulation of phosphorylation | kidney morphogenesis | regulation of intrinsic apoptotic signaling pathway | regulation of ossification | regulation of neuron differentiation | regulation of gene expression | regulation of retinal cell programmed cell death | regulation of extrinsic apoptotic signaling pathway | kidney epithelium development | axon development | regulation of mitochondrial membrane permeability | cellular response to stress | response to lipid | alpha-beta T cell lineage commitment | positive regulation of pigment cell differentiation | response to UV-B | positive regulation of cellular metabolic process | defense response to virus | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | response to axon injury | animal organ morphogenesis | developmental pigmentation | mitochondrial transport | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | regulation of cell-substrate adhesion | neuron apoptotic process | cell-substrate junction assembly | response to corticosteroid | regulation of cellular component movement | alpha-beta T cell differentiation | oogenesis | response to oxidative stress | pigmentation | axonogenesis | B cell homeostasis | positive regulation of cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | homeostasis of number of cells | positive regulation of cell migration | B cell activation | cell proliferation | leukocyte proliferation | neuron projection regeneration | regulation of cellular protein metabolic process | positive regulation of cell maturation | hindbrain development | phosphorylation | mesonephric epithelium development | negative regulation of ion transport | digestive tract development | response to toxic substance | regulation of apoptotic signaling pathway | protein phosphorylation | cell morphogenesis involved in differentiation | response to gamma radiation | mesonephros development | post-embryonic development | cation homeostasis | phosphate-containing compound metabolic process | sensory organ development | negative regulation of autophagy | mitochondrial membrane organization | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of intracellular pH | metanephros development | renal tubule development | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | lymphocyte homeostasis | negative regulation of calcium ion transport | regulation of protein metabolic process | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | renal system development | positive regulation of B cell activation | negative regulation of cell growth | regulation of viral process | apoptotic signaling pathway | negative regulation of calcium ion transport into cytosol | cell aging | intrinsic apoptotic signaling pathway in response to oxidative stress | regulation of mitotic cell cycle | nephron development | lymphocyte activation | positive regulation of molecular function | protein polyubiquitination | neuron differentiation | regulation of nitrogen utilization | multicellular organism reproduction | T cell differentiation | development of primary male sexual characteristics | ureteric bud morphogenesis | activation of immune response | multicellular organismal response to stress | fear response | protein metabolic process | positive regulation of protein modification process | regulation of growth | T cell selection | response to organic substance | gland development | T cell differentiation in thymus | protein ubiquitination | tissue morphogenesis | digestive system development | branching morphogenesis of an epithelial tube | regulation of pH | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | negative regulation of ossification | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | regulation of protein heterodimerization activity | cochlear nucleus development | cell surface receptor signaling pathway | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | mesenchymal cell differentiation | positive regulation of leukocyte activation | negative regulation of programmed cell death | male gonad development | negative regulation of mitotic cell cycle | positive T cell selection | ear development | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | chemical homeostasis | behavior | cell adhesion | regulation of myeloid cell apoptotic process | neuron projection development | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | cell death | nephron morphogenesis | pigment metabolic process | animal organ development | response to reactive oxygen species | regulation of cell activation | negative regulation of cellular component movement | alpha-beta T cell activation | ion homeostasis | protein modification by small protein conjugation or removal | regulation of striated muscle cell differentiation | regulation of phosphate metabolic process | cytoskeleton organization | antigen receptor-mediated signaling pathway | renal system process | T cell homeostasis | CD8-positive, alpha-beta T cell activation | positive regulation of muscle tissue development | vesicle organization | cell-cell adhesion | regulation of cellular pH | cell activation | oocyte development | morphogenesis of a branching epithelium | camera-type eye development | regulation of peptidyl-serine phosphorylation | negative regulation of cell cycle | positive regulation of developmental pigmentation | B cell lineage commitment | intracellular pH elevation | lymphocyte proliferation | regulation of cell communication | negative regulation of cell cycle G1/S phase transition | regulation of membrane permeability | dephosphorylation | negative regulation of signal transduction | transmembrane transport | positive regulation of developmental growth | signaling | positive regulation of growth | cell-matrix adhesion | regulation of protein binding | response to organic cyclic compound | cellular monovalent inorganic cation homeostasis | cell development | regulation of developmental growth | negative regulation of osteoblast proliferation | regulation of transmembrane transporter activity | extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of phosphorylation | cellular protein metabolic process | morphogenesis of a branching structure | anatomical structure morphogenesis | channel activity | response to biotic stimulus | reproductive structure development | axon regeneration | regulation of nervous system development | regulation of developmental process | regulation of ion transport | cell death in response to oxidative stress | melanocyte differentiation | endoplasmic reticulum calcium ion homeostasis | developmental process | organelle organization | regulation of muscle cell differentiation | behavioral defense response | cellular pigmentation | regulation of cell growth | peptidyl-serine phosphorylation | regulation of calcium ion transport | cellular protein modification process | B cell proliferation | tube development | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of B cell proliferation | negative regulation of cell proliferation | positive regulation of melanocyte differentiation | cellular metal ion homeostasis | epithelial cell differentiation | central nervous system development | positive regulation of metabolic process | ossification | positive regulation of neuron differentiation | immune system process | cellular metabolic process | regulation of viral genome replication | hematopoietic or lymphoid organ development | negative regulation of cell cycle process | female sex differentiation | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | positive regulation of cell motility | response to steroid hormone | lens fiber cell differentiation | regulation of viral life cycle | negative regulation of cell death | negative regulation of cell development | aging | divalent inorganic cation homeostasis | negative regulation of locomotion | sexual reproduction | nephron tubule development | negative regulation of cell differentiation | regulation of cellular component organization | response to ionizing radiation | lens development in camera-type eye | response to other organism | negative regulation of reactive oxygen species metabolic process | positive regulation of myotube differentiation | neural nucleus development | signal transduction | regulation of signaling | mesonephric tubule development | response to glucocorticoid | regulation of cell-matrix adhesion | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | organelle outer membrane | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | nuclear envelope | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | mitochondrial envelope | pore complex | membrane-enclosed lumen | outer membrane | mitochondrial membrane | cytosol | intracellular | myelin sheath | membrane
