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PubChem
| Name: | Biperiden |
|---|---|
| PubChem Compound ID: | 11220655 |
| Description: | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. |
| Molecular formula: | C21H29NO |
| Molecular weight: | 311.461 g/mol |
DrugBank
Identification
| Name: | Biperiden |
|---|---|
| Name (isomeric): | DB00810 |
| Drug Type: | small molecule |
| Description: | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. |
| Synonyms: |
Biperidene [INN-French]; Biperidine Hydrochloride; Biperidine; Biperideno [INN-Spanish]; Beperiden; Biperiden [Usan:Ban:Inn:Jan]; Biperidenum [INN-Latin]; Biperiden Hydrochloride; Biperidene Hydrochloride
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| Brand: | Akineton, Akinophyl |
| Category: | Muscarinic Antagonists, Parasympatholytics, Antidyskinetics, Antiparkinson Agents |
| CAS number: | 514-65-8 |
Pharmacology
| Indication: | For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy. |
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| Pharmacology: |
Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatm...
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| Mechanism of Action: |
Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum,...
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| Absorption: | 87% bioavailability |
| Protein binding: | 60% |
| Biotransformation: | The metabolism of biperiden is not completely understood, but does involve hydroxylation. |
| Toxicity: | LD50=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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