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QuickView for Gli1 (gene)


Gene Symbol:
GLI1 Homo sapiens Homo sapiens
Full name:
GLI family zinc finger 1
Synonyms:
GLI, zinc finger protein GLI1, GLI-Kruppel family member GLI1, glioma-associated oncogene 1, glioma-associated oncogene homolog 1 (zinc finger protein), oncogene GLI
Genomic Location:
Chr 12: 56140201-56152312
Description:
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants enco...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12q13.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cation binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | chromatin binding | cytoskeletal protein binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | microtubule binding | tubulin binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | brain development | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | developmental process involved in reproduction | regulation of cell cycle G1/S phase transition | positive regulation of striated muscle tissue development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | regulation of heart growth | cell differentiation | respiratory tube development | male gamete generation | nervous system development | cerebellum morphogenesis | regulation of DNA replication | anatomical structure regression | regulation of cardiac muscle cell proliferation | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | notochord morphogenesis | reproductive system development | canonical Wnt signaling pathway | multicellular organismal reproductive process | regulation of striated muscle tissue development | digestive tract morphogenesis | regulation of hepatocyte proliferation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | diencephalon development | regulation of canonical Wnt signaling pathway | regulation of smoothened signaling pathway | tissue development | regulation of cell differentiation | gamete generation | regeneration | regulation of cellular process | regulation of osteoblast differentiation | regulation of metabolic process | pituitary gland development | hepaticobiliary system development | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | urogenital system development | head development | response to stimulus | respiratory system development | metencephalon development | response to stress | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | regulation of cell cycle phase transition | reproduction | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | dorsal/ventral pattern formation | embryo development | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | Wnt signaling pathway | multicellular organism development | positive regulation of DNA replication | positive regulation of muscle organ development | cerebellum development | regulation of ossification | positive regulation of cell cycle | regulation of gene expression | positive regulation of cellular metabolic process | animal organ morphogenesis | liver development | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | epidermal cell differentiation | cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation | biosynthetic process | positive regulation of cardiac muscle cell proliferation | aromatic compound biosynthetic process | hindbrain development | digestive tract development | epidermis development | endocrine system development | positive regulation of cell cycle G1/S phase transition | proximal/distal pattern formation | cell communication | regulation of cellular metabolic process | liver regeneration | cerebellar cortex morphogenesis | positive regulation of signal transduction | positive regulation of cell proliferation | regulation of RNA metabolic process | embryonic morphogenesis | notochord development | multicellular organism reproduction | embryonic organ morphogenesis | positive regulation of organ growth | DNA-binding transcription factor activity | regionalization | regulation of growth | gland development | regulation of cardiac muscle tissue development | digestive system development | response to wounding | regulation of animal organ morphogenesis | ventral midline development | anatomical structure development | cell surface receptor signaling pathway | regulation of neural precursor cell proliferation | metabolic process | positive regulation of smoothened signaling pathway | regulation of RNA biosynthetic process | embryonic organ development | cerebellar cortex development | hindbrain morphogenesis | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | forebrain development | gene expression | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | regulation of Wnt signaling pathway | positive regulation of muscle tissue development | transcription, DNA-templated | lung development | smoothened signaling pathway | regulation of cell communication | negative regulation of signal transduction | positive regulation of developmental growth | signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of developmental growth | notochord regression | regulation of epithelial cell proliferation | anatomical structure morphogenesis | prostate gland development | cellular macromolecule biosynthetic process | regulation of organ growth | regulation of cerebellar granule cell precursor proliferation | reproductive structure development | regulation of nervous system development | regulation of developmental process | positive regulation of neural precursor cell proliferation | positive regulation of DNA metabolic process | developmental process | negative regulation of canonical Wnt signaling pathway | positive regulation of cell cycle process | spermatogenesis | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | ossification | osteoblast differentiation | positive regulation of cerebellar granule cell precursor proliferation | cellular metabolic process | positive regulation of cardiac muscle tissue development | sexual reproduction | positive regulation of signaling | signal transduction | regulation of signaling | animal organ regeneration | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | cell projection | nucleoplasm | plasma membrane bounded cell projection cytoplasm | cilium | cytoplasmic region | axoneme | membrane-bounded organelle | nucleus | organelle | ciliary plasm | membrane-enclosed lumen | ciliary base | cytosol | cytoskeleton | ciliary tip | intracellular