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QuickView for Glutethimide (compound)
PubChem
| Name: | Glutethimide |
|---|---|
| PubChem Compound ID: | 10176773 |
| Description: | A hypnotic and sedative. Its use has been largely superseded by other drugs. |
| Molecular formula: | C13H15NO2 |
| Molecular weight: | 217.264 g/mol |
DrugBank
Identification
| Name: | Glutethimide |
|---|---|
| Name (isomeric): | DB01437 |
| Drug Type: | small molecule |
| Description: | A hypnotic and sedative. Its use has been largely superseded by other drugs. |
| Synonyms: |
Glutathimid; Glutetimid; Glutetimide; Gluthetimide; Glutethimid
|
| Brand: | Sarodormin, Glimid, Doriden, Elrodorm, Ondasil, Gimid, Rigenox, Noxiron, Noxyron, Alfimid |
| Category: | Hypnotics and Sedatives |
| CAS number: | 77-21-4 |
Pharmacology
| Indication: | For the treatment of insomnia. |
|---|---|
| Pharmacology: | Glutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. Before long, however, it had become clear that glutethimide was just as likely to cause addiction and caused similarly severe withdrawal symptoms. |
| Mechanism of Action: | Glutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10%) to morphine. The general sedative effect also adds to the power of the combination. |
| Absorption: | Variable |
| Biotransformation: | Hepatic. Glutethimide is almost completely metabolized. |
| Route of elimination: | glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces. |
| Half Life: | 10-12 hours |
| Toxicity: | In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported. |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
Enzymes
