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QuickView for Anisindione (compound)

Name: anisindione
PubChem Compound ID: 2197
Molecular formula: C16H12O3
Molecular weight: 252.265 g/mol
Anisin indandione; SMR000146452; BRN 1880681; A2429/0102869; 2-(4-Methoxy-phenyl)-indan-1,3-dione; Anisindione; KBio1_000336; 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione; 2-(p-Methoxyphenyl)-1,3-indandione; 1H-Indene-1,3(2H)-dione, 2-(4-methoxyphenyl)-.
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Name: anisindione
Name (isomeric): DB01125
Drug Type: small molecule
Anisin indandione
Brand: Miradon, Unidone
Category: Anticoagulants
CAS number: 117-37-3
Indication: For the prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the prophylaxis and treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion.
Anisindione is a synthetic anticoagulant and an indanedione derivative. It is prescribed only if you cannot take coumarin-type anticoagulants such as coumadin as anisindione is a powerful drug with serious potential side effects. Anticoagulants decrease the clotting ability of the blood and therefore help to prevent harmful clots from forming in th...
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Mechanism of Action:
Like phenindione, to which it is related chemically, anisindione exercises its therapeutic action by reducing the prothrombin activity of the blood. Anisindione prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carb...
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Absorption: Accumulation does not occur with repeated dosing.
Protein binding: Not Known
Half Life: Not Known
Toxicity: An overdose is likely to cause abnormal bleeding, for which the symptoms include: bleeding from gums or nose, blood in urine or stools, excessive bleeding from minor cuts, patches of discoloration or bruises on the skin.
Affected organisms: Humans and other mammals
Drug interaction:
Nalidixic AcidThe quinolone antibiotic, nalidixic acid, may increase the anticoagulant effect of anisindione.
PropylthiouracilThe anti-thyroid agent, propylthiouracil, may decrease the anticoagulant effect of anisindione.
AmiodaroneAmiodarone may increase the anticoagulant effect of anisindione.
AminoglutethimideAminoglutethimide may decrease the anticoagulant effect of anisindione.
AcetaminophenAcetaminophen increases the anticoagulant effect of anisindione. Monitor for changes in the therapeutic and adverse effects of anisindione if acetaminophen is initiated, discontinued or dose changed.
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