Name: | anisindione |
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PubChem Compound ID: | 2197 |
Molecular formula: | C16H12O3 |
Molecular weight: | 252.265 g/mol |
Synonyms: |
Anisin indandione; SMR000146452; BRN 1880681; A2429/0102869; 2-(4-Methoxy-phenyl)-indan-1,3-dione; Anisindione; KBio1_000336; 2-(4-Methoxyphenyl)-1H-indene-1,3(2H)-dione; 2-(p-Methoxyphenyl)-1,3-indandione; 1H-Indene-1,3(2H)-dione, 2-(4-methoxyphenyl)-.
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Name: | anisindione |
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Name (isomeric): | DB01125 |
Drug Type: | small molecule |
Synonyms: |
Anisin indandione
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Brand: | Miradon, Unidone |
Category: | Anticoagulants |
CAS number: | 117-37-3 |
Indication: | For the prophylaxis and treatment of venous thrombosis and its extension, the treatment of atrial fibrillation with embolization, the prophylaxis and treatment of pulmonary embolism, and as an adjunct in the treatment of coronary occlusion. |
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Pharmacology: |
Anisindione is a synthetic anticoagulant and an indanedione derivative. It is prescribed only if you cannot take coumarin-type anticoagulants such as coumadin as anisindione is a powerful drug with serious potential side effects. Anticoagulants decrease the clotting ability of the blood and therefore help to prevent harmful clots from forming in th...
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Mechanism of Action: |
Like phenindione, to which it is related chemically, anisindione exercises its therapeutic action by reducing the prothrombin activity of the blood. Anisindione prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carb...
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Absorption: | Accumulation does not occur with repeated dosing. |
Protein binding: | Not Known |
Half Life: | Not Known |
Toxicity: | An overdose is likely to cause abnormal bleeding, for which the symptoms include: bleeding from gums or nose, blood in urine or stools, excessive bleeding from minor cuts, patches of discoloration or bruises on the skin. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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