QuickView for Dicumarol (compound)

Dwukumarol [Polish]; Dufalone; Dicoumarolum [INN-Latin]; NCGC00016296-01; NSC 17860; 4,4'-Dihydroxy-3,3'-methylene bis coumarin; NSC 221570; 5-19-06-00682 (Beilstein Handbook Reference); Bis-3, 3'-(4-hydroxycoumarinyl)methane; CAS-66-76-2.
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Dwukumarol [Polish]; Dufalone; Dicoumarolum [INN-Latin]; NCGC00016296-01; NSC 17860; 4,4'-Dihydroxy-3,3'-methylene bis coumarin; NSC 221570; 5-19-06-00682 (Beilstein Handbook Reference); Bis-3, 3'-(4-hydroxycoumarinyl)methane; CAS-66-76-2; NSC41834; Temparin; 3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one); Bis-3,3'-(4-hydroxycoumarinyl)methane; DivK1c_000896; Dicumarol; Bishydroxycoumarin; 3, 3'-Metilen-bis (4-idrossi-cumarina); 3,3'-Methylenebis(4-hydroxycoumarin); Dicoumarol; D03798; Dicumol; Dicumarolo [DCIT]; uncoupler of oxidative respiration; Acadyl; Dicumarine; HSDB 3223; AIDS-016070; 2H-1-Benzopyran-2-one, 3,3'-methylenebis[4-hydroxy- (9CI); AI3-14546; C00796; 3, 3'-Methylene-bis (4-hydroxycoumarine); 3,3'-Methyleen-bis(4-hydroxy-cumarine) [Dutch]; 2H-1-Benzopyran-2-one, 3,3'-methylenebis(4-hydroxy-; Coumarin, 3,3'-methylenebis[4-hydroxy-; CBDivE_003005; KBio1_000896; Spectrum2_000144; Di-4-hydroxy-3,3'-methylenedicoumarin; KBio2_005781; BRN 0335444; AIDS016070; Prestwick0_000785; ZINC00020258; Dicumarinum; 2H-1-Benzopyran-2-one, 3,3'-methylenebis[4-hydroxy-; 3, 3'-Methylenebis[4-hydroxy-1,2-benzopyrone]; 3, 3'-Methyleen-bis (4-hydroxy-cumarine); 3, 3'-Methylen-bis (4-hydroxy-cumarin); 3, 3'-Methylenebis[4-hydroxycoumarin]; Spectrum4_000508; Dicumarol [INN-Spanish]; Melitoxin; NC 034; 2H-1-Benzopyran-2-one), 3,3'-methylenebis(4-hydroxy-; Cuma; Cumid; Spectrum_000165; Bis-3,3'-(4-oxycoumarinyl)ethylacetate; Dicoumal; Dicumaol R; Dicumarolum; NSC221570; SPBio_000248; Dicumarol (USAN); Dicumarol [USAN]; Dicoumerol; 3,3'-Methylen-bis(4-hydroxy-cumarin) [German]; bis-hydroxycoumarin; Coumarin, 3,3'-methylenebis(4-hydroxy-; 3,3'-Metilen-bis(4-idrossi-cumarina) [Italian]; SPBio_002829; KBio2_000645; 3,3'-Methylenebis[4-hydroxy-2H-1-benzopyran-2-one]; 2H-1-Benzopyran-2-one], 3,3'-methylenebis[4-hydroxy-; KBioGR_001055; DTC; Di-4-hydroxy-3, 3'-methylenedicoumarin; KBioSS_000645; Anathrombase; KBio3_001393; NINDS_000896; BHC; Kumoran; ChemDiv2_003436; Acavyl; Antitrombosin; NSC17860; Trombosan; Spectrum3_000387; NSC 41834; 3,3'-Methylenebis[4-hydroxycoumarin]; 3,3'-Methylenebis[4-hydroxy-1,2-benzopyrone]; Baracoumin; Prestwick1_000785; Di-(4-hydroxy-3-coumarinyl)methane; Dicuman; EINECS 200-632-9; Bis(4-hydroxycoumarin-3-yl)methane; Prestwick_90; CCRIS 3713; 3,3'-Methylenebis(4-hydroxy-1,2-benzopyrone); Dicoumarin; 3,3'-Methylene-bis(4-hydroxycoumarine) [French]; KBio2_003213; Coumarin, 3,3'-methylenebis[4-hydroxy- (8CI); 66-76-2
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Bishydroxycoumarin; Dicoumarol; BHC; Dicoumarin; Bis-Hydroxycoumarin

Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. ...
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Dicumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
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