QuickView for H2AFY;jsessionid=DE9C0339192D6CEE6EF0469DC0C4C057 (gene)
- Gene Symbol:
- H2AFY
Homo sapiens - Full name:
- H2A histone family member Y
- Synonyms:
- H2A.y, H2A/y, H2AF12M, MACROH2A1.1, mH2A1, macroH2A1.2, core histone macro-H2A.1, histone H2A.y, histone macroH2A1, histone macroH2A1.1, histone macroH2A1.2, medulloblastoma antigen MU-MB-50.205
- Genomic Location:
- Chr 5: 134697970-134763476
- Description:
-
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction...
- Orthologs:
- Mus musculus , Rattus norvegicus , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q31.1
GO Molecular Function
sequence-specific DNA binding | kinase binding | protein kinase regulator activity | transcription regulatory region DNA binding | protein serine/threonine kinase inhibitor activity | core promoter binding | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | nucleosome binding | enzyme binding | nucleic acid binding | protein-containing complex binding | enzyme inhibitor activity | molecular function regulator | chromatin binding | RNA polymerase II core promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | promoter-specific chromatin binding | protein heterodimerization activity | nucleosomal DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | chromatin DNA binding | kinase inhibitor activity | protein dimerization activity | rDNA binding | RNA polymerase II regulatory region sequence-specific DNA binding | core promoter sequence-specific DNA binding | enzyme regulator activity | double-stranded methylated DNA binding | heterocyclic compound binding
GO Biological Process
negative regulation of phosphorylation | regulation of cell cycle process | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of cellular localization | regulation of localization | protein kinase regulator activity | nucleosome organization | regulation of transcription by RNA polymerase I | establishment of localization | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | negative regulation of RNA biosynthetic process | protein serine/threonine kinase inhibitor activity | negative regulation of protein phosphorylation | regulation of organelle organization | regulation of chromosome segregation | cellular process | regulation of gene expression, epigenetic | localization | chromatin organization | kinase regulator activity | regulation of mitotic nuclear division | protein kinase inhibitor activity | negative regulation of histone phosphorylation | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of histone modification | dosage compensation | regulation of cell cycle | negative regulation of cellular metabolic process | regulation of cell differentiation | negative regulation of histone methylation | regulation of cellular process | regulation of metabolic process | cellular component organization | regulation of histone methylation | enzyme inhibitor activity | regulation of cellular protein localization | negative regulation of histone H3-K27 methylation | positive regulation of epidermal cell differentiation | negative regulation of protein kinase activity | regulation of cell cycle phase transition | regulation of epithelial cell differentiation | protein-DNA complex assembly | cellular localization | regulation of gene silencing | negative regulation of metabolic process | cellular component assembly | molecular function regulator | regulation of nucleic acid-templated transcription | regulation of cell cycle G2/M phase transition | regulation of histone phosphorylation | positive regulation of organelle organization | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | negative regulation of cell cycle G2/M phase transition | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | negative regulation of cellular protein localization | positive regulation of chromosome organization | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | regulation of epidermis development | negative regulation of gene expression, epigenetic | establishment of protein localization to chromosome | regulation of keratinocyte differentiation | regulation of nitrogen compound metabolic process | negative regulation of protein serine/threonine kinase activity | regulation of transcription by RNA polymerase II | positive regulation of gene expression, epigenetic | protein localization to organelle | negative regulation of protein localization to chromosome, telomeric region | positive regulation of cell differentiation | regulation of cellular protein metabolic process | cellular protein-containing complex assembly | regulation of histone H3-K27 methylation | negative regulation of transcription of nucleolar large rRNA by RNA polymerase I | negative regulation of transcription by RNA polymerase I | protein localization to chromatin | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of sister chromatid cohesion | regulation of protein metabolic process | regulation of histone H3-K4 methylation | regulation of protein phosphorylation | regulation of RNA metabolic process | regulation of mitotic cell cycle | regulation of sister chromatid cohesion | protein-containing complex assembly | kinase inhibitor activity | regulation of kinase activity | chromatin assembly or disassembly | regulation of sister chromatid segregation | establishment of protein localization to organelle | positive regulation of keratinocyte differentiation | negative regulation of histone H3-K4 methylation | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | positive regulation of chromosome segregation | regulation of phosphate metabolic process | DNA packaging | regulation of chromosome organization | regulation of chromatin silencing at rDNA | establishment of protein localization | chromatin assembly | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of mitotic sister chromatid segregation | negative regulation of chromosome organization | negative regulation of molecular function | regulation of transcription, DNA-templated | protein localization | enzyme regulator activity | cellular macromolecule localization | establishment of protein localization to chromatin | regulation of developmental process | organelle organization | positive regulation of cell cycle process | positive regulation of epithelial cell differentiation | negative regulation of transcription by RNA polymerase II | DNA conformation change | positive regulation of epidermis development | nucleosome assembly | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | negative regulation of cell cycle process | regulation of protein localization | positive regulation of maintenance of mitotic sister chromatid cohesion | regulation of cellular component organization | regulation of epidermal cell differentiation | positive regulation of mitotic nuclear division | protein localization to chromosome | positive regulation of gene expression | regulation of chromatin organization | regulation of phosphorus metabolic process
GO Cellular Component
PcG protein complex | chromosome | intracellular membrane-bounded organelle | catalytic complex | chromosome, centromeric region | cell | nuclear lumen | ESC/E(Z) complex | sex chromosome | nucleolus | sex chromatin | nucleosome | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | protein-DNA complex | nucleoplasm | Barr body | chromatin | nuclear chromosome | vesicle | transferase complex | pericentric heterochromatin | extracellular exosome | chromosome, telomeric region | extracellular region | membrane-bounded organelle | extracellular vesicle | heterochromatin | nucleus | organelle | extracellular space | nuclear heterochromatin | membrane-enclosed lumen | X chromosome | nuclear chromatin | nuclear chromosome, telomeric region | intracellular | condensed chromosome
