QuickView for HMGA1a (gene)

Gene Symbol:

HMGA1 Homo sapiens

Full name:

high mobility group AT-hook 1

Synonyms:

HMG-R, HMGA1A, HMGIY, high mobility group protein HMG-I/HMG-Y, high mobility group protein A1, high mobility group protein R, high-mobility group (nonhistone chromosomal) protein isoforms I and Y, nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y

Genomic Location:

Chr 6: 34312628-34321986

Description:

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isofo...

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This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E12_Q6 ,  TCTGGAC_MIR198 ,  GATTGGY_NFY_Q6_01 ,  MYOD_Q6_01 ,  SP1_01 ,  MAZR_01 ,  TGANTCA_AP1_C ,  TTTGCAG_MIR518A2 ,  ETS_Q4 ,  TTANTCA_UNKNOWN ,  MZF1_01 ,  RYTTCCTG_ETS2_B ,  E2F1_Q4_01 ,  CACGTG_MYC_Q2 ,  E2F4DP1_01 ,  STAT6_02 ,  MAX_01 ,  TEL2_Q6 ,  TACTTGA_MIR26A_MIR26B ,  ARNT_02 ,  E2A_Q2 ,  MAF_Q6 ,  MYCMAX_B ,  GGGAGGRR_MAZ_Q6 ,  CAGGTG_E12_Q6 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  EGR_Q6 ,  MYOD_Q6 ,  ATGCTGC_MIR103_MIR107 ,  ACTACCT_MIR196A_MIR196B ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  E2F1DP2_01 ,  HIF1_Q5 ,  NERF_Q2 ,  MGGAAGTG_GABP_B ,  CTCTGGA_MIR520A_MIR525 ,  PAX6_01 ,  SPZ1_01 ,  E2F1DP1_01 ,  E2F_Q4_01 ,  GFI1_01 ,  BACH1_01 ,  MTF1_Q4 ,  WGGAATGY_TEF1_Q6 ,  E2F_02 ,  E2F4DP2_01 ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  CDC5_01 ,  ELK1_02 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  ETS1_B ,  E2F_Q3_01 ,  HIF1_Q3 ,  GGGTGGRR_PAX4_03 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-124u

Cytogenetic Map:

6p21.31

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