QuickView for HOS (gene)

Gene Symbol:

TBX5 Homo sapiens

Full name:

T-box 5

Synonyms:

HOS, T-box transcription factor TBX5, T-box protein 5

Genomic Location:

Chr 12: 113276118-113330630

Description:

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may...

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This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  SP1_01 ,  GATA1_03 ,  FOXJ2_02 ,  P53_DECAMER_Q2 ,  GATA3_01 ,  AML_Q6 ,  GATA_Q6 ,  SRY_01 ,  GATAAGR_GATA_C ,  FAC1_01 ,  STAT1_03 ,  COUP_01 ,  RFX1_01 ,  GATA1_04 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  AML1_01 ,  OSF2_Q6 ,  HNF4_01 ,  PAX4_02 ,  GTGACGY_E4F1_Q6 ,  ATF_01 ,  CDX2_Q5 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  TST1_01 ,  NKX62_Q2 ,  GGGCGGR_SP1_Q6 ,  LMO2COM_02 ,  GATA6_01 ,  AHR_Q5 ,  NKX61_01 ,  HSF2_01 ,  GATA1_02 ,  RACCACAR_AML_Q6 ,  RNGTGGGC_UNKNOWN ,  AML1_Q6 ,  CEBP_Q3 ,  TTGTTT_FOXO4_01 ,  WTTGKCTG_UNKNOWN ,  SMAD4_Q6 ,  T3R_Q6 ,  TGACAGNY_MEIS1_01 ,  ER_Q6_02 ,  SRY_02 ,  AACTTT_UNKNOWN ,  ACAGGGT_MIR10A_MIR10B ,  PAX2_02 ,  COREBINDINGFACTOR_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-27

Cytogenetic Map:

12q24.21

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